Intro to Immunology and Generalized Response to Infection Flashcards
Role of the immune system
- kill or control pathogens
- control disease
- Repair tissue damage
- organ development
- maintain organ integrity and function
Pathogens directly and indirectly damge tissues through
exotoxins and endotoxin
Direct mechs of tissues damage by pathogens
- exotoxin production
- endotoxin
- direct cytopathic effect
indirect mechs of tissues damage by pathogens
- immune complexes
- anti-host antibody
- cell-mediated immunity
pathogen present the immune systsem with challenges
- form diversity
- life cycle diversity
- diverse routs of infection
- Rapid, targeted response over a broad domain
(innate imm) Granulocytes cells
neutrophil
eosinophil
basophil
monocyte
Adaptive immunity cells
B and T cells
common lymphoid progenitor cells
T, B, plasmsa Cells? NK?
common myeloid cells
neutrophil eosinophil basophil monocyte mast
adaptive is common
lymphoid precursor
innate is common
myeloid precursor
lymphocytes are
active and in active T and B cells
leukocytes are
innate and adaptive cells
monocytes are
macrophages and dendritic
Granulocytes are
neutrophil
eosinophil
basophil
mast
____ are the primary response
neutrophils
primary antigen presenting cells
dendritic
macrophage
B lymphocyte
naive lymphocytes are activated in
lymph nodes
humaral immunity is
antibodies released by b cells
CD8 = MCH
I
CD4 = MCH
II
T cells are activated by
dendritic cell
antigen presentation activates
lymphocytes
CD8 T Cells:
cytotoxic
CD4 T Cells:
Regulatory
time/duration of innate for inflammation, complement activation, phago, destruction of path
minutes, days
time/duration interaction between antigen presenting dend. and antigen specific T: recongnition of antigen, adhesion, co stim, T-cell prolif and diff
hours, days
time/duration of activation of antigen-specific B cells
hours, days
time/duration of formation of effector and memory t cells
hours, days
time/duration of interaction of t cells with b cells, formation of germinal centers. formation of effector B cells and memory b cells. production of antibody
days, weeks
time/duration of emigration of effector lymphocytes from peripheral lymphoid organs
a few days, weeks
time/duration of effector cells and antibodies eliminate the pathogen
a few days, weeks
time/duration of maintance of mem B and T cells
days-weeks, can be life long
