Intro to hematopoietic system

Question 1

Components of blood

Answer 1

plasma (55%), buffy coat (<1%), erythrocytes- RBCs/ haematocrit (45% for healthy male, 42% for female)

Question 2

Functions of plasma

Answer 2

• transportation of nutrients, electrolytes and hormones
• immune defense
• haemostasis

Question 3

Functions of RBCs

Answer 3

transport of oxygen

Question 4

Components of buffy coat and their functions

Answer 4

• platelets (haemostasis)
• leukocytes (immune defense)

Question 5

Explain heamatopoietic development

Answer 5

• in early fetal development, majority of haematopoiesis occurs in liver/spleen
• after birth is in bone marrow
• early childhood, bone marrow in large bones (femur, tibia) responsible for production of blood cells
• adulthood -> bone marrow from trunk/core in body involved in production of blood cells
• adults w/ severe anemia -> liver/spleen regain fn to produce RBC to compensate for lack of production from bone marrow -> enlarged liver/spleen

Question 6

Extra-medullary sites vs medullary sites

Answer 6

• extra-medullary sites -> when haematopoiesis takes place in liver/spleen
• medullary sites -> whn haematopoiesis takes place in bone marrow

Question 7

All blood cells originate from which cell and what are some of it’s features?

Answer 7

Multipotent haematopoietic stem cell
- self renewal upon stimulation y growth factors
- found in bone marrow
- present in small amt

Question 8

What does multipotent haematopoietic stem cell differentiate into in lymphoid organs

Answer 8

lymphoid stem cell

Question 9

What does multipotent haematopoietic stem cell differentiate into in bone marrow

Answer 9

myeloid stem cell

Question 10

Further differentiation of lymphoid stem cell?

Answer 10

B and T cell

Question 11

Further differentiation of myeloid stem cell

Answer 11

Innate immunity cells (neutrophil, eosinophil, basophil)

Monocyte

Platelets

RBCs