intro to hematology Flashcards

1
Q

reduction in total number of RBCs, amount of Hb or RBC mass in circulation

A

anemia

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2
Q

increase in total number of RBCs, Hb and RBC mass in circulation

A

Polycythemia

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3
Q

variation in size, RDW > 14.5%

A

Anisocytosis

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4
Q

variation in shape

A

Poikilocytosis

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5
Q

increased in reticulocytes in the peripheral blood stream due to being released prematurely is called ?

A

Polychromasia

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6
Q

central pallor > 1/3rd the size of RBC

A

hypochromia

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7
Q

abnormally smaller RBC, lower MCV

A

microcytosis

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8
Q

abnormally large RBC, high MCV

A

macrocytosis

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9
Q

irregularly spiculated RBC (i.e. abetalipoproteinemia)

A

Acanthocyte

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10
Q

RBCs with short, regular spicules (i.e. uremia)

A

Echinocyte

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11
Q

RBC without central pallor

A

Spherocyte
i.e.hereditary spherocytosis

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12
Q

Elliptical RBC

A

Ovalocyte
(i.e. hereditary elliptocytosis)

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13
Q

Fragmented, bi- or tripolar spiculated RBC (i.e DIC)

A

Schistocyte

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14
Q

bipolar spiculated RBC (i.e.sickle cell disease)

A

sickle cell

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15
Q

Mouth-like deformity (i.e.hereditary stomatocytosis)

A

Stomatocyte

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16
Q

RBC with concentric circles (i.e. thalassemias)

A

target cell

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17
Q

unipolar spiculated RBC (i.e. myelofibrosis)

A

tear drop

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18
Q

whole blood comprise ____% of total body weight

A

7-8%

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19
Q

avg male have __ pints of blood, while avge female have ___ pints

A

12, 9

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20
Q

5 functions of blood

A
  1. oxygen and nutrient transportation
  2. blood loss prevention - clotting
  3. immune response to fight infection
  4. carries waste to kidney and liver
  5. body temp regulation
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21
Q

4 components of whole blood

A
  1. plasma
  2. RBC
  3. WBC
  4. platelets
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22
Q

where do blood cells come from?

A

produced in bone marrow
extramedullary sites include liver and spleen

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23
Q

plasma is mostly ___ absorbed from _____

A

water and salt
intestinal lining

24
Q

translucent, thin fluid that transports blood cells, proteins, etc., and helps maintain blood pressure

A

plasma

25
Q

plasma is composed of 90% water, the remainder is (5)

A
  1. proteins
  2. hormones
  3. insulin
  4. electrolytes
  5. nutrients
26
Q

most abundant blood cell

A

RBC

27
Q

primary role of RBC

A

oxygenation of tissues

28
Q

RBC production is stimulated by __

A

erythropoietin

29
Q

lifespan of RBC

A

120 d

30
Q

primary role of WBC

A

fight off foreign cells (infection)

31
Q

5 types of WBC

A
  1. neutrophil
  2. lymphocyte
  3. monocyte
  4. eosinophil
  5. basophil
32
Q

which WBC is the most abundant and what is their lifespan

A

neutrophil, <1d

33
Q

erythropoietin comes from the __

A

kidneys

34
Q

cell fragment, without a nucleus, helps with clotting, stimulated by thrombopoietin
lifespan of 7-10d

A

platelets

35
Q

thrombopoietin released by ____

A

liver and kidney

36
Q

increased WBC

A

leukocytosis

37
Q

decreased WBC

A

leukopenia

38
Q

increased RBC

A

erythrocytosis

39
Q

decreased RBC

A

erythrocytopenia

40
Q

why do males and females have a different normal RBC range?

A

different sex hormones

41
Q

a 4-part protein molecule that carries O2 and CO2

A

hemoglobin

42
Q

5 variables for hemoglobin

A
  1. sex - higher hgb in males
  2. age - higher hgb in young infants
  3. high alt/smokers - higher hgb
  4. pregnancy - lower hgb
  5. ethnicity - slight variations among each group
43
Q

a ratio of volume of RBC to volume of blood is called ?
formula?

A

hemotocrit
Hct = hgb * 3

44
Q

the amount (weight) of hemoglobin per RBC, directly related to RBC size

A

mean corpuscular hemoglobin MCH

45
Q

low MCH =

A

hypochromia

46
Q

high MCH =

A

hyperchromia

47
Q

what lab value shows the color of RBC

A

MCH

48
Q

avg hgb conc in each RBC is called ?

A

mean corpuscular hemoglobin concentration (MCHC)

49
Q

what is the difference between MCHC vs MHC

A

MCHC measurement (%) takes the volume or size of the red blood cell into account while MCH (#) does not

50
Q

measures the % of RBC that fall out of normal range in size, directly related to changes in MCV

A

red cell distribution width RDW

51
Q

increased RDW in condition that alter RBC size (high/low MCV) and with reticulocytosis

A

anisocytosis

52
Q

low plt =

A

thrombocytopenia

53
Q

high plt =

A

thrombocytosis/thrombocythemia

54
Q

reflects avg size of platelets

A

mean platelet volume (MPV)

55
Q

increased MPV with increased platelet production means

A

younger platelets are larger in size

56
Q

manually assesses blood cell morphology and cell count, visualization of neoplastic cells derived from bone marrow

A

peripheral blood smear