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PHAR 350 > Intro to Geriatrics > Flashcards

Intro to Geriatrics Flashcards

1
Q

What is the problem with using 65 years as the marker for senior?

A

With increased diversity with age, protocols and guidelines are less useful in geriatric care than for younger ages
- Care must be individualized

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2
Q

What are some factors that affect health in older age? (5)

A
  1. Genetics
  2. SES
  3. Education
  4. Social engagement and support
  5. Lifestyle: Exercise, diet, smoking, and alcohol use
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3
Q

Define life expectancy

A

To what proportion of the max age a person may live

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4
Q

Define health span

A

Number of years that are spent free from functional limitations, morbidity, and pain

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5
Q

The goal of most geriatric models of care is to _______ the ______ ____

A

prolong the health span

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6
Q

Functional capacity is an indicator of ability to carry out everyday tasks. What are the 2 groups of activities?

A
  1. Activities of Daily Living (ADLs)
    - Dressing, toileting, eating, bathing, walking
  2. Instrumental Activities of Daily Living (IADLs)
    - Shopping, housekeeping, food preparation, medication management, financial management
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7
Q

A helpful mnemonic for activities of daily living (ADLs) is BATTED - should know it

A

Bathing
Ambulation
Toileting
Transfers
Eating
Dressing

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8
Q

A helpful mnemonic for instrumental activities of daily living (IADLs) is SCUM - should know it

A

Shopping
Cooking/cleaning
Using telephone or transportation
Managing money and medications

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9
Q

What is functional reserve?

A

Body systems generally have capabilities beyond what is needed for everyday activities
- e.g., average adult’s cardiac output ~5L/min. Trained athlete’s cardiac output ~40-50L/min

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10
Q

How does functional reserve compare in older adults vs. younger adults

A

Older adults have decreased functional reserve compared to younger adults
- Increased risk of decline when faced with illness or injury
- E.g., older adult with dementia is more likely to experience post-operative delirium

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11
Q

What is functional decline?

A

Reduction in ability to perform ADLs and IADLs due to decreased physical and/or cognitive function

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12
Q

Age is a factor in functional decline and health resource utilization, but not the only factor. What else plays a role?

A

Higher healthcare utilization was reported among those with more chronic medical conditions, regardless of age

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13
Q

What changes in absorption are associated with aging? (4)

A
  1. Decreased gastric acid secretion
  2. Slower gastric emptying
  3. Delayed intestinal transit
  4. Decreased blood flow
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14
Q

Generally speaking when aging there is decreased rate of drug absorption (first-dose, prns) but no change in extent of drug absorption. What are the exceptions (that is, decreased gastric acid secretion may decrease the extent of absorption of which meds)? (3)
How might we combat this? (2)

A
  1. Iron supplements
  2. Ketoconazole/intraconazole
  3. Calcium carbonate
    Suggestions to combat:
  4. Empty stomach with iron supplements
  5. Use citrate form of calcium
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15
Q

How is percutaneous absorption affected due to aging? Give 3 medication examples

A

Decreased rate of percutaneous absorption of lipophyllic meds
1. Fentanyl
2. Testosterone
3. Estradiol

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16
Q

How does body composition change with aging? (2)

A
  1. 25-30% increase in body fat
  2. 25-30% decrease in muscle mass/body water
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17
Q

What are 2 highly lipophilic meds whose distribution is altered in older adults?

A
  1. Diazepam
  2. Amiodarone
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18
Q

What are 2 highly hydrophillic meds whose distribution is altered in older adults?

A
  1. Lithium
  2. Aminoglycoside antibiotics
19
Q

How do albumin levels change in older adults? What are 2 examples of meds which would be affected by this?

A

Decreased albumin levels in frail/malnourished older adults decreases protein-binding of highly-protein-bound medications
- Phenytoin
- Warfarin

20
Q

How does liver size and blood flow change with age?

A

Liver size and blood flow decrease significantly with age
- 20-40% decrease in liver mass
- ~35% decrease in hepatic blood flow

21
Q

Drugs with high first-pass extraction will have _________ bioavailability in older adults

A

increased

22
Q

What are some drugs with high first-pass extraction to be aware of? (5)

A
  1. Morphine
  2. Metoprolol, propranolol, labetalol
  3. Verapamil
  4. Amitriptyline
  5. Levodopa
    (Start low go slow)
23
Q

What changes in Phase I metabolism do we see in aging? What does that mean for the pt?

A

Some reduction in Phase I (CYP-450-mediated) metabolism with aging
- Longer half-lives - decreased dose requirements or increased dosing intervals

24
Q

What changes in Phase II metabolism do we see in aging?

A

Gotcha - there are none

25
Q

What are some meds that are metabolized via Phase II? (4)

A
  1. Acet
  2. Lorazepam, oxazepam, temazepam
  3. Zaleplon
  4. VPA
26
Q

How does elimination change with age?

A

Decreased renal size, blood flow, GFR, and tubular secretion
- ~10% decrease in GFR per decade after age 30

27
Q

Serum creatinine alone is not reliable to estimate kidney function in older adults. Why? (2)

A
  1. Muscle mass tends to decrease with age, so SCr may be falsely low
  2. Does not account for the effect of age on kidney function
28
Q

What are some of the equations that can be used to estimate kidney function? (3)

A
  1. CKD-epi
  2. MDRD
  3. Cockroft-Gault
29
Q

When does the Cockroft-Gault equation underpredict and overpredict renal function?

A
  1. Underpredicts renal function for those weighing less than their ideal body weight (IBW)
  2. Overpredicts renal function for those weighing more than their IBW
    - If overweight/obese - use IBW to calculate CrCl
30
Q

Mrs. G is an 87 year old woman being started on digoxin, which is a very water-soluble medication. How would we expect the volume of distribution of digoxin to be altered in Mrs. G based on her age?
a. Vd would increase
b. Vd would decrease
c. Vd would not be expected to change

A

b.

31
Q

Based on the anticipated pharmacokinetic alterations of digoxin in Mrs. G, we should choose an initial digoxin dose that is:
a. Higher than usual
b. Lower than usual
c. The same as usual

A

b.

32
Q

Lorazepam is mainly metabolized by Phase II hepatic metabolism (glucuronidation). In older adults, we would expect the metabolism of lorazepam to be:
a. Decreased (slower) than in younger adults
b. Increased (faster) than in younger adults
c. Unchanged compared to younger adults

A

c.

33
Q

Mr. A is a 79 year old man with a serum creatinine of 100mcmol/L (normal range is 45-90mcmol/L). He is starting gabapentin, a medication that requires dosage adjustment for renal impairment. Based on this information, you:
a. Start at half the usual recommended dose of gabapentin
b. Recommend a BID dosing regimen instead of the usual TID
c. Check his weight and calculate his CrCl to determine if dosage adjustment is needed
d. Calculate his eGFR using the MDRD, and use this to determine if dosage adjustment is required

A

c.

34
Q

Changes in medication response associated with aging is due to what?

A

Changes in receptor sensitivity, or altered homeostatic mechanisms

35
Q

How might cardiovascular medication response change in older adults? (4)

A
  1. Decreased blood pressure-lowering response to beta-blockers
  2. Decreased arterial compliance and decreased baroreceptor reflex
    - Predispose to orthostatic hypotension
  3. Increased stiffness of large blood vessels –> isolated systolic hypertension
  4. Increased susceptibility to QT prolongation
36
Q

How might CNS medication response change in older adults? (3)

A
  1. Increased permeability of BBB with age
  2. Increased susceptibility to CNS adverse effects of medications
    - Anticholinergics
    - Benzodiazepines
    - Dopaminergic medications
  3. Decreased dopaminergic neurons in substantia-nigra –> increased susceptibility to EPS side effects of dopamine-blocking meds
37
Q

How does fluid and electrolyte homeostasis change in older adults? (4)

A
  1. Decreased thirst response
  2. Decreased GFR
  3. Decreased response to antidiuretic hormone
  4. Decreased response to aldosterone
38
Q

In terms of fluid and electrolyte homeostasis, older adults are more susceptible to: (4)

A
  1. Dehydration
  2. Hyponatremia
  3. SIADH
  4. Hyperkalemia
39
Q

How does hematopoietic reserve change in older adults? What does that do?

A

Decreases
- Increased risk of hematological toxicities associated with chemotherapeutic drugs

40
Q

In older adults, there is a(n) _________ response to antiepileptic drugs at a lower serum concentration

A

increased
(also increased susceptibility to adverse effects)

41
Q

What is immunosenescence? (3)

A
  1. Reduced ability to fight infections
  2. Reduced immune response following vaccination
  3. Increased susceptibility to malignancy
42
Q

In older adults there is _________ regenerative capacity of gastric mucosa which leads to?

A

decreased
- leads to increased risk for GI bleeds

43
Q

How does therapeutic window change for older adults?

A

It narrows, which can be a problem for some medications

PHAR 350 (6 decks)

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