Intro to Endo

Question 1

What does biofilm resistance result in?

Answer 1

1) Antimicrobials may fail to penetrate beyond the surface layers of the biofilm
(2) Antimicrobials may be trapped and destroyed by enzymes
(3) Antimicrobials may not be active against non-growing microorganisms
(4) Expression of biofilm-specific resistance genes (e.g., efflux pumps)
(5) Stress response to hostile environmental conditions (e.g., leading to an overexpression of antimicrobial agent-destroying enzymes).

Question 2

What are features of apical periodontitis?

Answer 2

• Chronic poly-microbial infection
• Stimulation of host response
• Connective tissue destruction

Question 3

What does periradicular disease usually cause?

Answer 3

tooth loss/severe infection

Question 4

What are the objectives of RCT?

Answer 4

removing canal contents
eliminating infection