Intro to CNS Flashcards

1
Q

Roles of the Brain stem?

A

Regulation of vital body functions: cardiovascular, respiratory, digestion.

Role in balance & posture.

Maintenance of cortical arousal (including sleep).

Source of most cranial nerves including the special senses: sight, hearing, smell, taste.

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2
Q

What does the Brain stem consist of?

A

Midbrain

Pons

Medulla Oblongata

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3
Q

The Brain stem is a source of what major monoamine cell bodies:

A

Noradrenaline — Locus coeruleus

5-HT (Serotonin) — Raphe nuclei

Dopamine — Substantia nigra/ Ventral tegmentum

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4
Q

Roles of the Midbrain?

A

Relay centre for visual, auditory, and motor system information.

It regulates autonomic functions, those that the body carries out without conscious thought, such as digestion, heart rate, and breathing rate.

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5
Q

Roles of the Pons?

A

Regulation of breathing.

Involved in the transmission of signals to and from other structures in the brain, such as the cerebrum or the cerebellum.

Involved in sensations such as hearing, taste, and balance.

Also involved in the regulation of deep sleep.

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6
Q

Roles of the Medulla Oblongata?

A

Regulation of heart rate and blood pressure.

Responsible for many reflexes in the body, or involuntarily controls, such as vomiting, sneezing, and coughing.

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7
Q

Major functions of the Cerebellum:

A

Important role in maintaining balance.

Regulates and maintains muscle tone.

Coordinates voluntary movement.

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8
Q

What does the Diencephalon consist of?

A

Thalamus

Hypothalamus

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9
Q

Role of Thalamus?

A

The thalamus functions as a relay station/hub for all sensory impulses to the cerebral cortex

Preliminary processing of sensory data (including vision and sound).

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10
Q

Role of Hypothalamus?

A

Regulates release of hormones from the pituitary gland.

It controls the Autonomic Nervous System (ANS).

It coordinates communication between nervous system and endocrine systems.

It controls body temperature (measured by blood flowing through it).

It regulates hunger/thirst and feelings of satiety.

It assists with the internal circadian clock by
regulating biological activity

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11
Q

Functions of the Basal Ganglia?

A

Operation of motor programmes.

Regulation of muscle tone.

Implicated in control of mood.

Coordinates voluntary movement.

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12
Q

What 2 pathways does the Basal Ganglia use?

A

Direct - Involved in making a movement.

Indirect - Involved in preventing an unwanted movement.

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13
Q

Functions of the Limbic system?

A

Control of “Primitive emotions”: fear, anger, pleasure, reward (Amygdala functions).

Control of “Complex emotions”: social awareness, madness, mood, Memory formation (Memory=hippocampus).

Executive functions: Planning, organisation, attention.

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14
Q

What is the Corpus Callosum?

A

Connection Centre for the two brain halves.

Allows the two hemispheres to communicate and coordinate their activities.

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15
Q

What protects CNS from injury?

A

CNS enclosed in hard, bony structures (skull).

CNS surrounded by 3 strong, protective membranes (meninges).

Brain “floats” in CSF (cerebrospinal fluid).

Blood-brain barrier (BBB) restricts access from circulation.

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16
Q

Factors affecting access of drugs into CNS:

A

Lipid solubility – Oil: water partition co-efficient.

Proportion of free unionised drug in plasma:

· pKa of drug.
· Blood Ph.
· Extent of protein binding.

17
Q

What does the left cerebral hemisphere control?

A

Right handedness

Spoken language

Written Language

Scientific skills

Numerical skills

Logical reasoning

18
Q

What does the right cerebral hemisphere control?

A

Left handedness

Musical awareness

Recognition of faces

Artistic skills

Creativity

19
Q

What are the 4 areas found in the cerebrum?

A

The primary visual area is located at the posterior tip of the occipital lobe mainly on the medial surface.

The primary gustatory area is located just inferior to the primary somatosensory area.

The primary auditory area is in the superior part of the
temporal lobe.

The primary olfactory area is in the inferomedial temporal lobe.

20
Q

What is the role of the reticular activating system (RAS)?

A

The RAS functions to maintain consciousness, a state of wakefulness in which an individual is fully alert, aware, and oriented.

21
Q

what are the 4 Fs involved in the hypothalamus?

A

Fight
flight
food
sexual and reproductive behaviour

22
Q

How do you measure brain activity

A

Electroencephalogram (EEG)