Intro To Chem Path Flashcards

1
Q

What is chemical pathology?

A

Chemical pathology is the study of the biochemical basis of a disease, the biochemical application and the molecular diagnostic techniques.

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2
Q

What are the roles of Chemical Pathology in healthcare?

A
  1. Diagnosis.
  2. Screening.
  3. Prognosis.
  4. Monitoring.
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3
Q

What is diagnosis?

A

Diagnosis refers to differentiating between several possibilities of a disease or ailment through using the patient’s initial history or examinations.

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4
Q

What is screening?

A

To screen for the presence of a particular disease in an otherwise healthy population.

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5
Q

What is Prognosis?

A

It refers to the prediction of disease susceptibility by observing health trends.

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6
Q

What is monitoring?

A

Refers to check a disease progression or response to treatment.

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7
Q

What are fluoride oxalate tubes used for?

A

To prevent erythrocyte glycolysis using us blood glucose

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8
Q

How do you prevent Bilirubin and B-carotene from photo degrading?

A

By putting them in aluminum foil.

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9
Q

Factors to consider when taking a blood sample.

A
  1. Venostasis
  2. Posture of patient
  3. Site of venipuncture
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10
Q

Changes that occur in the blood after collection.

A
  1. Diffusion of K+, lactase dehydrogenase, asparate transaminase through the red blood cells into the serum/plasma.

2.Decrease in glucose concentration due to erythrocyte glycolysis.

  1. Photo degradation of Bilirubin and B-carotene when expose to light.
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11
Q

What is limit of linearity?

A

The maximum reading ability, or the accuracy limit of a machine past which it cannot provide a value.

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12
Q

What is analytical sensitivity?

A

Refers to the ability to smallest amount or concentration of an analyte that can be detected.

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13
Q

What is analytical specificity?

A

The ability to test for a particular analyte.

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14
Q

What is precision?

A

Precision is when a set of values fall within a similar range of values.

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15
Q

What is accuracy?

A

When a value is the exact or similar to the value that is wanted.

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16
Q

What is clinical sensitivity?

A

Records the accurate number of people with a particular disease.

17
Q

What is clinical specificity?

A

The accurate number of people without the disease.

18
Q

What are positive and negative predictive values?

A

The extent to which TP is positive and TN is negative.

19
Q

What is clinical validation.

A

It follows technical validation and examine the probability of that an analytically correct result is accurate and useful for the patient.

20
Q

What is a delta check?

A

Involves cross checking a patient’s results against previous results to spot unusual changes to ensure patient safety.

21
Q

What is a range check?

A

Looks at the value for an analyte, to determine whether the result is physiologically possible.