Intro To Autonomic System Flashcards
Which presynaptic receptor provides feedback inhibition of NE
alpha2 receptors
Inhibition of alpha 2 receptor cause
Increase of NE
Location of alpha 1 receptors
- Blood vessels of skin, viscera, kidney , salivary glands
2. Most sympathetic organs (except heart)
Location of alpha 2 receptors
Platelets Vascular smooth muscles Exocrine gland of pancreas Never terminals Fat cells
Beta 1 receptor location
Heart - + ve chronotrophic and inotrophic
kidney- increase renin production
Which adrenergic receptors are inhibitory(hyperpolarize)
Alpha 2
Beta 2
Which receptor binds only to epinephrine
Beta 2
Action of alpha 2 and G protein
G protein- Gi
- constriction of vasculature
- Inhibit lipolysis
- Inhibit insulin secretion
- Increase platelet aggregation
- Inhibit transmitter release
- Decrease secretions
Action of beta 2receptors G protein
G protein- Gs
- Dilation of bronchiole
- Dilation of blood vessels to lund and heart
- Lipolysis
- Glycogenolysis
- Decrease motility of GIT
- Tremors of skeletal muscles
- Relaxation of urinary bladder
- Increase HR and force
Where are beta 3 receptor found
Fat cells
Location and function of D1 receptors
- Splanchnic vessels-dilates
2. Renal vessels- dilate
D2 receptor location and function
Presynaptic nerve terminals- inhibit adenylyl cyclase
Mechanism of action of alpha 1
- Ligand binds
- Gq protein activated
- Activates PLC
- Hydeolyzes PIP2
- Form DAG and IP3
- IP3 cause increase in intracellular Ca2+
- Ca bind calmodulin cause phosphorylation
Mechanism of alpha 2
- Activation Gi
- Inhibits adenylyl cyclase - dec cAMP
- activate K+ channels or inhibit voltage gates Ca2+ channels
Beta receptor with least affinity
Beta 3 but is resistant to desensitization
G protein of D1
Gs - activates adenylyl cyclase-increase cAMP- vasodilation of renal and splanchnic vessels