Intro to antihypertensives

Question 1

Blood pressure equation

Answer 1

MAP= CO x TPR

Question 2

4 major categories of antihypertensive agents

Answer 2

1. Diuretics
2. Agents that block production or action of angiotensin
3. Direct vasodilators
4. Sympathoplegic agents

Question 3

Order of action in the nephron

Answer 3

1. Acetazolamide
2. Osmotic agents
3. Loop agents
4. Thiazides
5. Aldosterone antagonists
6. ADH antagonists

Question 4

Diuretic categories

Answer 4

Carbonic anhydrase inhibitors, loop diuretics, thiazide diuretics, K sparing diuretics

Question 5

Diuretics usage

Answer 5

• Increase the rate of urine flow and Na excretion
• Used to adjust volume or comp of body fluids in different clinical situations: CHF, kidney disease and renal failure, cirrhosis, HTN, nephrolithiasis, hypercalcemia, and DI