Intro to ADME Flashcards
what is pharmacokinetics (PK)?
How body handles drugs. What process is the drug exposed to when it is in the body. Most of these will be measured in plasma concentration, it gives an indication if the drug has reached systemic circulation. You need to link the concentration with that needed at the site of action.
what is pharmacodynamics (PD)?
what drug does to the body
what is absorption?
- All processes from site of administration to site of measurement
what is bioavailabilty?
defined here as a measure of the extent of absorption of unchanged administered compound
what is distrubtion?
Reversible transfer of substance between site of measurement and other sites within the body
what is metabolism?
Irreversible loss of unchanged substance by chemical conversion (alters physchem properties of the drug)
what is excretion?
Irreversible loss of unchanged substance
what is elimination?
Irreversible loss of unchanged substance from site of measurement
what is disposition?
elimination and distribution
what is behaviour is a function of?
- Physicochemical and structural properties of drug
- Dosage form
- Route of drug administration – i.v., oral, i.m.
- Physiology of the body
what factors may influence the PK of a drug?
genetics, size, age, disease, co-administration of other drugs, environmental factors (smoking)
what is the single equation for PK model for ADME?
C = C0e-kt
