Intro Stuff

Question 0

Secondary/specific granules

Answer 0

• stain different colors depending: basophils-blue bawls, eosinophils-bright red, neutrophilic-salmon
• lactoferrin, lysozyme, Alkaline Phosphatase

Question 1

Primary granules

Answer 1

• coarse reddish (azeurophilic)

- myeloperoxidase, defensins

Question 2

CGD

Answer 2

• CGDXL: gp91
• CGDAR: gp67/gp47
• ineffective phagocytic killing: no NADPH oxidase -> no O2-
• no oxidation of NBT: blue is bad

Question 3

Reactive leukocytosis

Answer 3

• > 12,000
• elevation in LAP
• absence of abnormal cells, accompanies infectious/inflammatory process
• chronic: “left shift” (left = less mature cells), precursors in marrow increase
• release decreases as condition resolves

Question 4

Congenital neutropenia

Answer 4

• marrow cells only progress to myelocytic stage
• severe neutropenia (almost no mature functional neutrophils)
• Hx of recurrent infections/hospitalizations