Intro Quiz

Question 1

Which of the following is classified under classical cytogenetics?

a. CGH b. FISH c. G- banding d. Alphoid probes

Answer 1

c

Question 2

The pioneering effort of this scientist led to the first attempts to determine the number of chromosomes using laboratory techniques.

a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming

Answer 2

c

Question 3

In the laboratory, chromosomes are stained to allow proper visualization and increase the contrast. This technique was pioneered by.

a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming

Answer 3

d

Question 4

The pioneering effort of this scientist led to the first attempts to determine the number of chromosomes using laboratory techniques

a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming

Answer 4

c.

Question 5

Chromosomal crossover between homologous chromosomes is important because it results in new combinations of of genes different from either parent, contributing to genetic diversity. This process was first theorized by:

a. Erwin Chargaff
b. Cyril Dean Darlington
c. Frederick Griffith
d. Walter Stanborough Sutton

Answer 5

d

Question 6

British scientist _____’s application of radiation science was truly historic. The scientist’s work with x-ray crystallography contributed to the double-helix structure of the DNA molecule

a. Erwin Chargaff
b. Cyril Dean Darlington
c. Rosalind Franklin
d. Walter Stanborough Sutton

Answer 6

c

Question 7

Who among the following scientists discovered the process of horizontal gene transfer by which some bacteria take up foreign material (naked DNA) from the environment?

a. Erwin Chargaff
b. Cyril Dean Darlington
c. Frederick Griffith
d. Walter Stanborough Sutton

Answer 7

c.

Question 8

Which of the following is the pioneering contribution of Wilhelm von Waldeyer in the field of cytogenetics?

a. The naming of chromosomes based on anatomical-morphological concepts
b. The enumeration of the number of chromosomes from a human sample
c. The use of culture techniques to allow the study of chromosomes

Answer 8

a.

Question 9

Watson and Crick was credited for the discovery of the ____ DNA structure

Answer 9

double-helix

Question 10

The first correct karyotype of a human diploid chromosome is credited to

a. Morgan, Sturtevant, Bridges, & Muller
b. Moorehead and colleagues
c. Sutton & Boveri
d. Tijo & Levan

Answer 10

d

Question 11

Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden

called the microorganisms that he found everywhere in vast numbers “animalcules”

Answer 11

A

Question 12

Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden

Observed nucleus in a plant cell shile studying the process of fertilization in the year 1831

Answer 12

B

Question 13

Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden

In 1694, in de sexu plantarum (on the sex of the plants), _______ produced a clear experimental evidence for the sexuality of plants

Answer 13

C

Question 14

Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden

He believed that the long neck of giraffes evolved as generations of giraffes reached for ever higher leaves

Answer 14

D.

Question 15

Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden

“All living things are composed of one or more cells; the cell is the basic unit of life, and new cells arise from existing cells”

Answer 15

E

Question 16

Identify: Its mechanism of action include tubulin depolymerization & disruptjon if mitotic spindles

Answer 16

Colchicine

Question 17

Aniline dyes are ____, and this is the reason why they stick to nucleic acids which are acidic in nature

Bonus: Aniline is derived from which material

Answer 17

Basic, coal tar

Question 18

Identify the kind of chromosome discovered by Painter in insects

Answer 18

polytene

Question 19

____ represents an individual’s complete set of chromosomes. The term also refers to a laboratory-produced image of a person’s chromosomes isolated from an individual cell and arranged in numerical order

Answer 19

karyotype

Question 20

This principle states that the amount of cytosine was very close to equaling the amount of guanine, or A = T and G = C

Answer 20

Chargaff’s rule

Question 21

P_____ studies include techniques such as amniocentesis followed by FISH

Answer 21

Prenatal

Question 22

Prenatal screens are useful for the studies of chromosomal a_____n and a______y

Answer 22

aberration, aneuploidy

Question 23

FISH could also be used to study c_____, such as those that are a product of translocation, chromosomal gain or loss, or deletion of p53 gene

Answer 23

cancer

Question 24

The main focus of the study of cytogenetics is the nuclear content of the cell, particularly the _______

Answer 24

chromosomes

Question 25

Bonus: In CML, the fusion gene is detected in BCR:ABL FISH, in which the cell is in a generative but non-replicative phase

Answer 25

Interphase

Question 26

This technique for analysing solid tumors was first done by Kallioniemi and colleagues in 1992.Spell out

Answer 26

Comparative Genomic Hybridization