Intro Quiz Flashcards
Which of the following is classified under classical cytogenetics?
a. CGH b. FISH c. G- banding d. Alphoid probes
c
The pioneering effort of this scientist led to the first attempts to determine the number of chromosomes using laboratory techniques.
a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming
c
In the laboratory, chromosomes are stained to allow proper visualization and increase the contrast. This technique was pioneered by.
a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming
d
The pioneering effort of this scientist led to the first attempts to determine the number of chromosomes using laboratory techniques
a. Karl Wilhelm von Nageli b. Wilhelm von Waldeyer c. Theophilus Painter d. Walther Flemming
c.
Chromosomal crossover between homologous chromosomes is important because it results in new combinations of of genes different from either parent, contributing to genetic diversity. This process was first theorized by:
a. Erwin Chargaff
b. Cyril Dean Darlington
c. Frederick Griffith
d. Walter Stanborough Sutton
d
British scientist _____’s application of radiation science was truly historic. The scientist’s work with x-ray crystallography contributed to the double-helix structure of the DNA molecule
a. Erwin Chargaff
b. Cyril Dean Darlington
c. Rosalind Franklin
d. Walter Stanborough Sutton
c
Who among the following scientists discovered the process of horizontal gene transfer by which some bacteria take up foreign material (naked DNA) from the environment?
a. Erwin Chargaff
b. Cyril Dean Darlington
c. Frederick Griffith
d. Walter Stanborough Sutton
c.
Which of the following is the pioneering contribution of Wilhelm von Waldeyer in the field of cytogenetics?
a. The naming of chromosomes based on anatomical-morphological concepts
b. The enumeration of the number of chromosomes from a human sample
c. The use of culture techniques to allow the study of chromosomes
a.
Watson and Crick was credited for the discovery of the ____ DNA structure
double-helix
The first correct karyotype of a human diploid chromosome is credited to
a. Morgan, Sturtevant, Bridges, & Muller
b. Moorehead and colleagues
c. Sutton & Boveri
d. Tijo & Levan
d
Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden
called the microorganisms that he found everywhere in vast numbers “animalcules”
A
Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden
Observed nucleus in a plant cell shile studying the process of fertilization in the year 1831
B
Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden
In 1694, in de sexu plantarum (on the sex of the plants), _______ produced a clear experimental evidence for the sexuality of plants
C
Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden
He believed that the long neck of giraffes evolved as generations of giraffes reached for ever higher leaves
D.
Choices: A. Leeuwenhoek, B. Brown, C. Camerarius, D. Lamarck, E. Schwann-Schleiden
“All living things are composed of one or more cells; the cell is the basic unit of life, and new cells arise from existing cells”
E
Identify: Its mechanism of action include tubulin depolymerization & disruptjon if mitotic spindles
Colchicine
Aniline dyes are ____, and this is the reason why they stick to nucleic acids which are acidic in nature
Bonus: Aniline is derived from which material
Basic, coal tar
Identify the kind of chromosome discovered by Painter in insects
polytene
____ represents an individual’s complete set of chromosomes. The term also refers to a laboratory-produced image of a person’s chromosomes isolated from an individual cell and arranged in numerical order
karyotype
This principle states that the amount of cytosine was very close to equaling the amount of guanine, or A = T and G = C
Chargaff’s rule
P_____ studies include techniques such as amniocentesis followed by FISH
Prenatal
Prenatal screens are useful for the studies of chromosomal a_____n and a______y
aberration, aneuploidy
FISH could also be used to study c_____, such as those that are a product of translocation, chromosomal gain or loss, or deletion of p53 gene
cancer
The main focus of the study of cytogenetics is the nuclear content of the cell, particularly the _______
chromosomes
Bonus: In CML, the fusion gene is detected in BCR:ABL FISH, in which the cell is in a generative but non-replicative phase
Interphase
This technique for analysing solid tumors was first done by Kallioniemi and colleagues in 1992.Spell out
Comparative Genomic Hybridization
