Intro EBM

Question 1

Who realized that Pellegra had to do with nutritional deficiency?

Answer 1

Dr. Goldberger

Vit b3 (pyridoxine deficiency)

Question 2

Who designed 1st RCT?

Answer 2

Sir Bradford HIll (streptomycin-RUTGERSSS!)

Question 3

What are POEMS?

Answer 3

Patient Oriented Outcomes that MAtter

Question 4

What is external validity?

Answer 4

Confidence that the results can be accurately generalized to the population

Question 5

What do inclusion/exclusion criteria influence?

Answer 5

Control variability (internal validity)
Limit generalizabilty (external validity)

Question 6

What is selection bias?

Answer 6

Selection for data analysis in such a way that proper randomization is not achieved

Question 7

What is measurement bias?

Answer 7

Poorly measuring your outcome

Question 8

How do we want to address out searches for medical literature?

Answer 8

PICO

Patient
Intervention
Comparison
Outcome

Question 9

Using the ‘new’ EBM pyramid, where does DYNAMED fall? Pubmed?

Answer 9

Dynamed - summaries (right below ideal of systems)

Pubmed - studies

Question 10

List the ‘new’ ebm pyramid in descending order:

Answer 10

1. Systems
2. Summaries
3. Synopses of syntheses
4. Syntheses
5. Synopses of studies
6. Studies

Question 11

What is an example of synopses of studies?

Answer 11

ACP journal club

Question 12

What is a systematic review an example of?

Answer 12

Syntheses

Question 13

What is the Bradford-Hill Criteria for proving causality?

Answer 13

1. Temporality
2. Strength
3. Dose-response
4. Reversibility
5. COnsistency
6. Biologic plausibility
7. Specificity
8. Analogy