Intro Flashcards
What is the extracellular matrix and what is it made of?
A complex network of carbohydrates and proteins filling spaces between cells, comprised of both fibrillar and non fibrillar components.
Why does the ECM do?
It provides physical support and determines the mechanical and physicochemical properties of the tissue. It also influences the growth, adhesion and differentiation of the cells and tissues with which it interacts and is essential for development, tissue function and organogenesis.
Why should we be interested in ECM as a medical student?
Gene mutations affecting matrix proteins can cause a variety of diseases.
Gene mutations can also affect ECM catabolism
Fibrotic disorders due to excessive ECM deposition
Disorders due to excessive loss of ECM
