Intro Flashcards

1
Q

Classic endocrine glands

A
  • Pituitary (anterior and posterior)
  • Thyroid
  • Parathyroid
  • Adrenal
  • Pancreas (islets)
  • Gonads
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2
Q

Hormones secreted by hypothalamus

A
  • TRH
  • CRH
  • GnRH
  • GHRH
  • Somatostatin
  • Dopamine
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3
Q

Hormones secreted by anterior pituitary

A
  • TSH
  • FSH
  • LH
  • ACTH
  • MSH
  • GH
  • Prolactin
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4
Q

Hormones secreted by posterior pituitary

A
  • Oxytocin

- ADH

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5
Q

Hormones secreted by thyroid

A
  • T3
  • T4
  • Calcitonin
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6
Q

Hormones secreted by parathyroid

A

-PTH

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7
Q

Hormones secreted by pancreas

A
  • Insulin

- Glucagon

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8
Q

Hormones secreted by adrenal medulla

A
  • Norepi

- Epi

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9
Q

Hormones secreted by kidney

A
  • Renin

- 1,25-Dihydroxycholecalciferol

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10
Q

Hormones secreted by adrenal cortex

A
  • Cortisol
  • Aldosterone
  • Adrenal androgens
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11
Q

Where do peptide and amino acid hormones bind?

A

Receptors on the membrane. They are hydrophilic and can’t cross the cell membrane.

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12
Q

Where do steroid hormones bind?

A

Enter the cell and activate nuclear or cytoplasmic receptors.

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13
Q

Characteristics of steroid hormones

A
  • No storage pools
  • Diffuse through cell membrane
  • Receptor in cytoplasm or nucleus
  • Regulate gene transcription
  • Respond in hours to days
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14
Q

Characteristics of peptide-amine hormones

A
  • Storage pools in secretory vesicles
  • Receptor on cell membrane
  • Signal transduction cascade affects variety of processes
  • Respond in seconds to minutes
  • NOTE T3 and T4 can directly enter a cell
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15
Q

Pseudohypoparathyroidism

A
  • Molecular alterations in G proteins affect certain signaling systems
  • Abnormality in subunit alphaS in a heterotrimeric G protein
  • Impairment of PTH to regulate body calcium and phosphorus homeostasis
  • Low serum Ca and high serum phosphate levels
  • Have increased levels of PTH (it’s just not working correctly)
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16
Q

Where does the pituitary gland lie?

A

Sella turcica in the base of the brain

17
Q

Anterior pituitary

A
  • Adenohypophysis
  • Receives venus blood carrying neuropeptides from the hypothalamus and pituitary stalk
  • Hypophyseal portal circulation with pituitary
  • Produces protein and glycoprotein hormones
18
Q

Posterior pituitary

A
  • Neurohypophysis
  • Neural connections from hypothalamus (paraventricular nucleus and supraoptic nucleus)
  • Arterial blood
  • Produces ADH and oxytocin
19
Q

Release of growth hormone

A
  • Hypothalamus releases GHRH (inhibited by somatostatin)
  • Affects somatotroph in anterior pituitary
  • GH released
20
Q

Release of TSH

A
  • Hypothal releases TRH to thyrotroph in anterior pit

- TSH released to stimulate thyroid

21
Q

Release of ACTH

A
  • Hypothal releases CRH to cortiocotrophs in ant pit

- ACTH released to stimulate adrenal cortex

22
Q

Release of FSH and LH

A
  • Hypothal releases GnRH to gonadotrophs in ant pit

- FSH and LH released

23
Q

Prolactin and dopamine relationship

A
  • Prolactin under tonic inhibitory control by dopamine
  • TRH stimulates prolactin release
  • If pituitary stalk is severed prolactin will increase
  • Will also increase with a D2 receptor antagonist