Intro Flashcards
Classic endocrine glands
- Pituitary (anterior and posterior)
- Thyroid
- Parathyroid
- Adrenal
- Pancreas (islets)
- Gonads
Hormones secreted by hypothalamus
- TRH
- CRH
- GnRH
- GHRH
- Somatostatin
- Dopamine
Hormones secreted by anterior pituitary
- TSH
- FSH
- LH
- ACTH
- MSH
- GH
- Prolactin
Hormones secreted by posterior pituitary
- Oxytocin
- ADH
Hormones secreted by thyroid
- T3
- T4
- Calcitonin
Hormones secreted by parathyroid
-PTH
Hormones secreted by pancreas
- Insulin
- Glucagon
Hormones secreted by adrenal medulla
- Norepi
- Epi
Hormones secreted by kidney
- Renin
- 1,25-Dihydroxycholecalciferol
Hormones secreted by adrenal cortex
- Cortisol
- Aldosterone
- Adrenal androgens
Where do peptide and amino acid hormones bind?
Receptors on the membrane. They are hydrophilic and can’t cross the cell membrane.
Where do steroid hormones bind?
Enter the cell and activate nuclear or cytoplasmic receptors.
Characteristics of steroid hormones
- No storage pools
- Diffuse through cell membrane
- Receptor in cytoplasm or nucleus
- Regulate gene transcription
- Respond in hours to days
Characteristics of peptide-amine hormones
- Storage pools in secretory vesicles
- Receptor on cell membrane
- Signal transduction cascade affects variety of processes
- Respond in seconds to minutes
- NOTE T3 and T4 can directly enter a cell
Pseudohypoparathyroidism
- Molecular alterations in G proteins affect certain signaling systems
- Abnormality in subunit alphaS in a heterotrimeric G protein
- Impairment of PTH to regulate body calcium and phosphorus homeostasis
- Low serum Ca and high serum phosphate levels
- Have increased levels of PTH (it’s just not working correctly)