Intro Flashcards
What are the two types of immunity?
Innate and Adaptive
What makes up primary lymphoid tissue?
Bone marrow and thymus
What makes up secondary lymphoid tissue where response takes place?
Lymph nodes, spleen, diffuse lymphoid tissues (tonsils)
What does humoral immunity consist of?
Circulating Abs from programmed cells that will label and/or kill abnormal invaders
What does cellular immunity consist of?
Programmed cells directly killing abnormal cells, or producing growth factors (cytokines) to stimulate other cells
What do B lymphocytes do and what percentage of blood lymphocytes do they make up?
1) Mediate the humoral response by making antibodies
2) Clonal expansion if stimulated by interleukins from helper T cells
3) differentiate into plasma cells that secrete Abs
10-20%
What two Abs act as receptors on B cells and activate them?
IgM and IgD
What are antibodies?
Glycoproteins that interact with epitope of an antigen
What is the general structure of an antibody? Be able to draw it (see notes).
Y-shaped with heavy and light chains that are connected with disulfide bonds and non-covalent forces
What region of the antibody has the Ag binding site? How many of these sites are there per Ab?
Fab region - 2
What region of Ab is constant and determines the Ab class?
Fc region
Which Ab is a pentamer that activates complement?
IgM
Which Ab activates B cells?
IgM
Which Ab is the initial Ab that is expressed during a response?
IgM
Which Ab is most common in blood and is a monomer?
IgG