Intro Flashcards
DRUG MOVES FROM A HIGHER CONCENTRATION TO A LOWER CONCENTRATION ALONG A CONCENTRATION GRADIENT. NO ENERGY, NO CARRIER PROTEIN, NOT SATURABLE, MOST COMMON AND THE SLOWEST.
Passive Diffusion
DRUG MOVES FROM A HIGHER CONCENTRATION TO A LOWER CONCENTRATION ALONG A CONCENTRATION GRADIENT. NO ENERGY REQUIRED AND SATURABLE BUT HAS A SPECIALIZED TRANSMEMBRANE CARRIER PROTEIN.
Facilitated Diffusion
DRUG MOVES FROM A LOWER CONCENTRATION TO A HIGHER CONCENTRATION AGAINST A CONCENTRATION GRADIENT. ENERGY (ATP) REQUIRED, FASTEST, SATURABLE AND HAS A CARRIER PROTEIN
Active Transport
GOVERN’S DRUG DIFFUSION
Fick’s Law
ENERGY REQUIRING AND NEEDS VESICLE FOR TEMPORARY STORAGE.
Vesicular transport
ENGULFMENT OF THE DRUG, IT GOES INSIDE THE CELL.
Endocytosis
CELL EATING, ENGULLF LARGE MOLECULES OF DRUGS AND MICROORGANISM, LIMITED TO HOST CELLS (PHAGOCYTES), DEFENSE MECHANISM.
Phagocytosis
CELL DRINKING, ENGULF EXTRACELLULAR FLUID AND DISSOLVED SOLUTES, MAST CELLS PERFORM THIS FUNCTION.
Pino cytosis
FACTORS INFLUENCING ABSORPTION
• PH
• BLOOD FLOW AT THE ABSORPTION SITE
• SURFACE AREA
• CONTACT TIME AT THE ABSORPTION SURFACE
• EXPRESSION OF P GLYCOPROTEIN
(F) RTION OR FRACTION OR AMOUNT OF DRUG THAT REACHES THE SYSTEMIC CIRCULATION OR BLOOD STREAM. OR QUANTIFYING AMOUNT OF DRUG THAT REACHES THE BLOOD STREAM.
Bioavailability
FACTORS THAT INFLUENCE BIOAVAILABILITY
• FIRST PASS METABOLISM
• SOLUBILITY OF THE DRUG
• CHEMICAL INSTABILITY
• NATURE OF THE DRUG FORMULATION
SHOW COMPARABLE BIOAVAILABILITY AND SIMILAR TIME TO ACHIEVE BLOOD CONCENTRATION
Bioequivalence
SAME GN AND THERAPEUTIC MOIETY BUT DIFFERENT MANUFACTURER
Generic substitute
SAME GN DIFFERENT DOSAGE FORM
Pharmaceutic substitute
DIFFERENT GN BUT SAME CATEGORY OR CLASS
Therapeutic substitute
