intro

Question 1

Body of knowledge concerned with the action of chemicals on biological systems, especially by binding to regulatory molecules (receptors) and activating or inhibiting normal body processes

Answer 1

pharmacology

Question 2

Area of pharmacology concerned with the use of chemicals in the prevention, diagnosis,
and treatment of disease, especially in humans

Answer 2

medical pharmacology

Question 3

are of pharmacology concerned with the undesirable effects of chemicals on biologic systems

Answer 3

toxicology

Question 4

Finds the exact mechanism of action of drugs and identifies the receptors

Answer 4

pharmacogenomics

Question 5

Any substance that brings about a change in biologic function through chemical actions

Answer 5

drug

Question 6

Specific molecules in the biological system that play a regulatory role

Answer 6

receptor

Question 7

Inorganic ions, nonpeptide organic molecules, small peptides and proteins, nucleic acids, lipids, and carbohydrates

Answer 7

the nature of drugs

Question 8

Found in plants or animals, many are partially or completely synthetic

Answer 8

the nature of drugs

Question 9

[synthetic or not]

hormones

Answer 9

synthetic

Question 10

[synthetic or not]

xenobiotics

Answer 10

not synthesized, it is a foreign substance in the body

Question 11

whats the physical nature of drugs

Answer 11

■ solid [aspirin, atropine, tablets]
■ liquid [nicotine, ethanol]
■ gas [nebulizers, xenon]

Question 12

for selective binding

Answer 12

100 MW

Question 13

For traversing to different barriers of the body

Answer 13

1000 MW

Question 14

Cannot move within the body and given directly at the site of action

Answer 14

> 1000 MW

Question 15

■ stereoisomerism
■ exist as enantiomeric pairs

Answer 15

chirality

Question 16

isomer, potent beta receptor blocker

Answer 16

carvedilol (S) (-)

Question 17

isomer weak beta receptor blocker

Answer 17

carvedilol (R) (+)

Question 18

(+) more potent anesthetic and less toxic than the (-)

Answer 18

ketamine

Question 19

■ Chemical forces or bonds through which the drug interacts with the receptors
■ Weaker bonds are more selective bonds

Answer 19

drug receptor bonds

Question 20

■ strongest
■ irreversible

Answer 20

covalent bonds

Question 21

■ more common
■ weaker
■ Eg, between cation and an anion

Answer 21

electrostatic bonds

Question 22

■ weakest
■ highly lipid soluble drugs

Answer 22

hydrophobic bonds

Question 23

drug-body interactions

Answer 23

■ pharmacodynamics
■ pharmakokinetics