Intrinsic Resistance Flashcards
Aerobic GNR (2)
Clindamycin
Vancomycin
Non-glucose-fermenting GNR: Pseudomonas (oxidase +) Burkholdereria (oxidase +) Acinetobacter (oxidase -) Stenotrophomonas (oxidase -) (1)
Ertapenem
Burkholderia cepacia complex (
Penicillins 1st and 2nd generation cephalosporins Cephamycins Ertapenem Colisitn Fosfomycin
SPICE organisms
(chromosomal AmpC betalactamase) Penicillins (except piperacillin) Amp/sulbactam Amox/clav 1st/2nd gen cephalosporins, cephamycins
Exposure -> de-repression of ampC gene and resistance to:
3rd gen cephalosporins
Pip/tazo
Ertapenem
Citrobacter freundii complex
SPICE (de-repressible chromosomal Amp-C)
Citrobacter koseri
Ampicillin
Piperacillin
Ticaricillin
Enterobacter
Klebsiella aerogenes
SPICE
Klebsiella (not aerogenes)
Ampicillin
Ticarcillin
Proteae (Proteus, Morganella, Providencia)
Colistin Nitrofurantoin Tetracycline/tigecycline Imipenem SPICE
Pseudomonas aeroginosa
Ampicillin Amp/sulbactam 1st/2nd gen cephalosporins Cephamycins Ceftriaxone Ertapenem Trimethoprim-sulfamethoxazole Nitrofurantoin
Salmonella/shigella
Aminoglycosides
1st/2nd generation cephalosporins and cephamycins
Serratia marcescens
Nitrofurantoin
Colistin
SPICE
Stenotrophomonas maltophila
Penicillins Amp/sulbactam Amox/clav Pip/tazo 1st-3rd generation cephalosporins except ceftazidime Cephamycins Aztreonam Carbapenems Aminoglycosides Tetracycline Fosfomycin
Aerobic GP organisms
Colistin
Polymixin B
Nalidixic acid
Enterococcus
Cephalosporins
Aminoglycosides
Clindamycin
Trimethoprim-sulfamethoxazole