Intracellular pH Flashcards
1
Q
Why is pH tightly regulated in the body
A
pH changes can cause a change in net electrical charge on protein & other biological molecules
2
Q
How does pH change affect the body
A
-disrupts electrostatic interactions & H-bonds
-alters protein structures & function
-alters binding of substrates & ligands
3
Q
Extracellular pH
A
7.35-7.45
4
Q
Cytoplasmic pH
A
7.2
5
Q
What cellular processes are highly pH sensitive
A
Calcium homeostasis
Cell communication
Apoptosis
Mobility and contractility
Metabolism
Proliferation
6
Q
Clinical diseases resulting from intracellular pH dysregulation
A
Tissue ischaemia
Over-activation of Na-H exchanger
Altered cellular function (apoptosis, necrosis)
Dents disease
Defects in endocytosis as a result of mutation
