Intestinal Obstruction and Tumours Flashcards

1
Q

What are the 3 main causes of intestinal obstruction?

A

1) Contraction
2) Increased pressure
3) Blockage

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2
Q

What are 3 causes of blockage?

A

1) Tumour
2) Diaphragm disease (NSAIDs)
3) Gallstones in bladder (rare)

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3
Q

What are 3 causes of contraction?

A

1) Hirschsprung’s disease
2) Inflammation
3) Intramural Tumours

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4
Q

How is intestinal obstruction caused by Crohn’s disease?

A

1) Crohn’s disease –> Inflammation –> Fibrosis –> Contraction –> Obstruction

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5
Q

How does Diverticulitis cause the intestinal obstruction?

A

Outpouching of the mucosa, leads to faecal matter being trapped, inflammation in bowel wall, contraction leads to obstruction

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6
Q

What is Hirschsprung’s disease?

A

Congenital condition of lack of motility in the Bowel from lack of nerves, causing obstruction and gross dilation

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7
Q

What are 3 causes of pressure?

A

1) Volvulus
2) Adhesions
3) Peritoneal Tumour

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8
Q

What is a Volvulus and where will it most likely be seen?

A

Closed loop obstruction from twist/rotation in the Bowel, presenting a risk of necrosis
- Free floating sections of the bowel, e.g. mesentery –> Sigmoid colonic is long so can twist in on itself

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9
Q

Define and describe the causes of Adhesions

A

Def: Stuck together loops of bowel which distort and pull the bowel (Sec to surgery)
Desc: Secondary effect after abdominal surgery

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10
Q

What are 4 common adult causes of small bowel obstruction?

A
  1. Adhesions.
  2. Hernias.
  3. Crohn’s disease.
  4. Malignancy.
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11
Q

What are 3 common child causes of small bowel obstruction?

A
  1. Appendicitis.
  2. Volvulus.
  3. Intussusception.
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12
Q

Which type of Bowel obstruction is more common?

A

Small Bowel (Makes up 75%)

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13
Q

What is intussusception?

A

Part of the intestine invaginates into another section of the intestine -> telescoping. It is caused by force in-balances.

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14
Q

What is a Hernia?

A

Protrusion of part of the viscera into cavity into an area where doesn’t belong

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15
Q

What is the main risk of an untreated Hernia? What are the main symptoms?

A

Irreducible: Can’t return them to correct body cavity as can become strangulated
1) Palpable Lump 2) Abdominal pain

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16
Q

Would dilatation, distension and increased secretions be seen proximal or distal to an intestinal obstruction?

17
Q

What are main 5 symptoms of small bowel obstruction?

A
  1. Vomiting.
  2. Pain.
  3. Constipation.
  4. Distension.
  5. Tenderness.
18
Q

What are main signs of small bowel obstruction?

A

1) Increased vital signs
2) Resonance
3) Tenderness and Swelling
4) Bowel sounds

19
Q

What investigations would be done for small bowel obstruction?

A

1) Good Patient History
2) X-Ray
3) MRI, CT scan Ultrasound
4) FBC, U&E, and Lactate

20
Q

What is the main management and treatment for SBO?

A
  1. Fluid resuscitation.
  2. Bowel decompression.
  3. Analgesia and anti-emetics.
  4. Antibiotics.
  5. Surgery e.g. laparotomy, bypass segment, resection.
21
Q

What are the main causes and symptoms of LBO?

A

C: Volvulus, Colorectal Cancer
S: Tenesmus, Constipation, Bloating, Vomit, Weight Loss, Abdominal Discomfort

22
Q

What are the investigations and treatments for LBO?

A

I: DRE, Sigmoidoscopy, Plain X-Ray, CT
T: Fast patient, supplementary O2, IV fluids to replace losses and correct electrolyte, urinary catheterisation to monitor urinary output

23
Q

What are the 3 main causes of untreated intestinal obstructions?

A

1) Ischaemia
2) Necrosis
3) Perforation

24
Q

How does normal epithelium progress to colorectal cancer?

A

1) Normal epithelium
2) Adenoma
3) Colorectal adenocarcinoma
4) Metastatic adenocarcinoma

25
What is an adenocarcinoma?
Malignant tumour of glandular epithelium
26
What is familial adenomatous polyposis? | What is its PP?
C: Genetic condition causing development of thousands of polyps during teen years PP: Mutation in APC protein, so apc/GSK complex isn't formed and beta catenin levels increase, causing up-regulation of adenomatous gene transcription
27
How can adenoma formation be prevented?
NSAIDs
28
What is HNPCC and the treatment for it?
HNPCC: Inherited higher tendency to develop colorectal cancer T: No DNA repair proteins so risk of colonic and EM cancers
29
What is the treatment for colorectal adenocarcinoma?
Surgical resection can be done when there is no spread. Remember to balance risks v benefits. The patient has a pre-op assessment. If metastatic: Chemotherapy & Palliative Care
30
Why has Bowel Cancer survival increased and what are the main risk factors?
Increased: Colonoscopic Technique, Screening Programme, Treatment Options better RF: Alcohol, Smoking, Diet: Low fibre or High red meat, PMH of adenoma/ulcerative colitis, family history of CC (Presentation affected by proximity to rectum)
31
What are main signs of rectal cancer?
1. PR bleeding. 2. Mucus. 3. Thin stools. 4. Tenesmus.
32
What are the signs of Left and Right side sigmoid cancer?
L: PR Bleeding, Change of Bowel Habit R: Anaemia, Mass and non-settling Diarrhoea
33
What investigations might you do in someone who you suspect might have colorectal cancer?
Colonoscopy = gold standard! It permits biopsy and removal of small polyps. - Tumour markers are good for monitoring progress. - Faecal occult blood is used in screening but not diagnosis.
34
What are the emergency presentations of each type of cancer?
LHS: Narrow and most likely to show signs of obstruction RHS: Signs of perforation as RHS is wide