INTERSTITIUM

Question 1

Reticular opacities

Answer 1

• Interstitial Lung Disease (ILD):
  
  • Subpleural:
    
    • UIP
    • NSIP
      
      • Idiopathic
      • CTD related
    • Asbestosis
  • Peribronchovascular:
    
    • Sarcoid
    • Hypersensitivity pneumonitis (Cluster 2)
• Lymphangitis carcinomatosis
• Mimics:
  
  • Pulmonary oedema (especially superimposed on emphysema)
  • Cystic lung disease:
    
    • LAM
    • LCH

Question 2

Honey Combing

Answer 2

Clustered cysts (3-10mm) that share well-defined walls + stacked in rows of cysts

Subpleural:

• UIP
• NSIP
• Asbestosis

Peribronchovascular:

• Hypersensitivity pneumonitis (cluster 1 + 2)
• Sarcoidosis
• Hemosiderosis

Anterior:

• ARDS
• Unilateral abscence of pulmonary artery

Rare:

• Hermansky-Pudlak syndrome
• Sickle Cell disease

Question 3

Upper lung zone predominant disease

Answer 3

• TB
• Sarcoidosis
• Pneumoconiosis: silicosis/coal workers
• Hypersensitivity pneumonitis
• Centrilobular emphysema
• ABPA
• LCH
• Neurogenic pulmonary oedema
• Chronic eosinophilic pneumonia
• Pleuropulmonary fibroelastosis

Question 4

Lower lung zone predominant lung disease

Answer 4

• UIP: idiopathic, CTD, drug induced, asbestosis
• NSIP: idiopathic, CTD, drug induced
• Pulmonary oedema
• Aspiration
• Hematogenosu dissemination: mets/septic emboli
• Bronchiectasis
• HP
• OP
• LIP
• Acute interstitial pneumonia
• DIP