Internal Medicine EORE Flashcards
What is the most appropriate first-line therapy for a Black Patient with HTN?
thiazide type diuretic or calcium channel blocker (amlodipine) as initial monotherapy
What two electrolyte side effects are seen with thiazide diuretics?
hyponatremia and hypokalemia
What is the most common side effect of finasteride and why?
decreased libido, sexual dysfunction due its reduction in the conversion of testosterone to dihydrotestosterone preventing prostatic gland growth which is suspected to decrease nitric oxide in the corpus cavernosum
Most common side effects of tamsulosin?
orthostatic hypotension and floppy disc syndrome
What is the recommended screening age for prostate cancer?
55-65 and should be determined with shared decision making
Treatments for SIADH (5)
- treat underlying cause
- water restriction to approximately 500-1500mL per day
- correct sodium deficit
- vasopressin receptor antagonists
- Loop diuretic
Dilated cardiomyopathy may have coexisting
dysrhythmias such as atrial fibrillation due to dilated ventricles
adenocarcinoma is typically found in the _____ of the lung and is more common in patients who _______.
periphery of the lung and is more common in patients who do not smoke
Large cell lung cancer is typically located in
the outer regions of the lungs causing SOB and fatigue
Pancoast tumors are found in the ____ of the lung
apex of the lung and commonly cause symptoms of pain in the shoulder, neck, and shoulder blade
Small cell lung cancer is most closely associated with ______ and demonstrates ______ growth
smoking exposure
rapid
Types of non-small lung cancer
adenocarcinoma
squamous cell
large cell
location of small cell carcinoma
arise in central airways (hilar mass/ bulky mediastinal lymphadenopathy)
Treatment for prolactinomas
dopamine agonists:
cabergoline
bromocriptine
Transsphenoidal surgery indications for pituitary ademonas
with pituitary adenomas that do not respond to initial management with medications, large, or causing significant visual field deficits may be candidates for surgery
symptoms of a prolactinoma
galactorrhea
amenorrhea
loss of libido
vaginal dryness
dyspareunia
osteoporosis
What is contraindicated in a patient that is experiencing acute-closure glaucoma
atropine
what is it called when you have an incomplete relaxation of the lower esophageal sphincter and aperistalsis in the distal two-thirds of the esophagus
achalasia
best treatment for this condition (achalasia)
pneumatic balloon dilation
if refractory to this procedure then surgical intervention can be performed
What can cause pseudoachalasia
primary or metastatic tumors
What is the appearance on a barium swallow that indicates achalasia
bird-beak appearance
diagnostic test that confirms achalasia
esophageal manometry - shows increased LES pressure
what is the most common central nervous system infection in pts with AIDS who are not receiving appropriate ppx?
Cerebral toxoplasmosis
What is the imaging modality of choice for suspected cerebral toxoplasmosis? and what does it show?
MRI
often shows multiple ring-enhancing brain lesions which are assosicated with edema
treatment for cerebral toxoplasmosis
sulfadiazine and pyrimethamine as well as antiretroviral therapy for immune recovery
what is used for treatment of hepatic encephalopathy?
lactulose
what is the treatment for wernicke enceohalopathy
thiamine
What are two idiopathic inflammatory myopathies and are characterized by bilateral proximal muscle weakness?
polymyositis and dermatomyositis
Polymyositis is
disease with symmetrical, progressive proximal muscle weakness that occurs over a period of weeks to moths that affects the neck and muscle groups of the upper and lower extremities
face and eyes are spared
dermatomyositis is
polymyositis symptoms along with a dusky red heliotrope rash commonly seen around the eyes and facial erythema that mimics a butterfly shaped rash seen in patients with systemic lupus erythematosus however this rash includes the nasolabial folds unlike the malar rash in lupus
Polymyositis and dermatomyositis are associated with an increase incidence of
malignancy
how to test for polymyositis and dermatomyositis
EMG abnormalities
muscle bx shows chronic inflammation
elevated muscle enzymes
management of dermatomyositis
glucocorticoids
azathioprine, methotrexate
what drug is known to cause myopathy
statins