Internal Med - Endocrinology

Question 1

Glucagon

Answer 1

Secreted by Alpha Cells in the pancreas

Stimulates liver to GLUCONEOGENESIS- Conversion of Glycogen to Glucose

Metformin impairs the liver’s ability to respond to metformin thereby lowering blood glucose levels.

Question 2

Metformin MOA

Answer 2

MOA for Metformin remains not fully eleudicated but recent studies suggest it antagonizes glucagon in the liver interrupting glucagon-dependent gluconeogenesis.

2013 Feb 14;494(7436):256-60. doi: 10.1038/nature11808. Epub 2013 Jan 6.