Interleukins And Other Signals

Question 1

What molecule does dendrite use as a costimulatory molecule

Answer 1

B7 binding CD28 on T cell

Question 2

What happens when B7 binds CD28?

Answer 2

Pathway for activation of NFkB and NFAT begin, which ultimately creates IL2

Question 3

Job of IL2

Answer 3

It acts in auto crine manner to proliferate TCells

Question 4

What receptor binds CCL19 and 21 that is given off by HEV? (This receptor is on cells that want to enter node)

Answer 4

CCR7

Question 5

Th1 response

Answer 5

Macrophages and CD8

Question 6

TH2 response

Answer 6

Antiparasitic

Eosinophils and mast cells

Question 7

Th17 response

Answer 7

Granulocytic response involving neutrophils. Produce IL17 that then causing surrounding tissue to give off IL8 and bring in neutrophils

Question 8

Tfh response

Answer 8

B cell antibody response

Question 9

What IL does dendrite present to T cell ic it wants Th1 response

Answer 9

IL12

Question 10

What IL does dendrite give off if it wants TH2 response

Answer 10

IL4

Question 11

What IL does dendrite give off if it wants TH17 response

Answer 11

IL6

Question 12

After activated by IL12 what cytokine does TH1 cell make to activate macrophages

Answer 12

IFN gamma

Question 13

What cytokine do TH2 make to signal eosinophils and mast cells after activated by IL4

Answer 13

More IL4 and il5 this helps mast and eosinophils make IgE

Question 14

What cytokine does Th 17 make after being stimulated by IL6

Answer 14

Makes IL17–> which acts on surrounding tissues to make il8 and recruit neutrophils

Question 15

What does IL10 do

Answer 15

Regulatory T cells to help stop inflammation