Interleukins Flashcards
What is the clinical relevance of IL-1?
Implicated in pathogenesis of septic shock, rheumatoid arthritis and atherosclerosis
Which cells produce IL-1?
Macrophages
What is the major activity if IL-1?
T-cell activation and macrophages, promotion of inflammation
Which cells produce IL-2?
Type 1 helper T cells
Which cells produce IL-4?
Type 2 helper T cells, mast cells, eosinophils, basophils
Which cells produce IL-5?
Type 2 helper T cells, mast cells, eosinophils
Which cells produce IL-6?
Type 2 helper T cells, macrophages
Which cells produce IL-8?
T cells and macrophages
Which cells produce IL-11?
Bone marrow and stromal cells
Which cells produce IL-12?
Macrophages and B-cells
Which cells produce IL-17?
T cells
Which cells produce tumour necrosis factor-alpha?
macrophages, NK cells, T and B cells, mast cells
Which cells produce tumour necrosis factor-beta?
Type 1 helper T cells and B cells
Which cells produce transforming growth factor-beta?
T cells, macrophages, NK cells and B cells
GM-CSF is produced by?
T cells, macrophages, NK cells, B cells
Interferon- alfa is produced by?
Virally infected cells
Interferon- beta is produced by?
Virally infected cells
Interferon-gamma is produced by?
Type 1 helper T cells and NK cells
What is the major activity if IL-2?
Activation of lymphocytes, NK cells and macrophages
Which cells in the SI express Till-like receptors?
Endothelial, monocytes, macrophages, dendritic cells, enterocytes
What happens when TLRs bind PAMPs?
Production of nuclear transcription factor NF-kappa B, which is ubiquinated = transcription of pro-inflammatory cytokines
What happens when TLRs bind MAMPs?
Production of nuclear transcription factor NF-kappa B, ubiquinated BLOCKED = NO transcription of pro-inflammatory cytokines
What is the role of Toll like receptors in the SI?
Recognition of commensal versus invading bacteria.
Which ILs are produced by ubiquinated transcription factor NF-kappa B?
IL-6, IL-8, IL-1 beta and TNF-alpha
