interleukins Flashcards
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What cytokine activates macrophages
What cell release it
IFNg Th1 cells (induced by IL12)
TNFa is released from what cell
What is its effect
Macrophages
Fever and neutrophil chemotaxis
IL-2
Source:
Effect:
Source: Th1 cells
Effect: Stimulates growth and differentiation of T cell response
IL-3
Source:
Effect:
Source: Th1 cells
Effect: Stimulates differentiation and proliferation of myeloid progenitor cells
IL-4
Source:
Effect:
Source: Th2 cells
Effect: Stimulates proliferation and differentiation of B cells
IL-5
Source:
Effect:
Source: Th2 cells
Effect: Stimulate production of eosinophils
IL-6
Source:
Effect:
Source: Macrophages, Th2 cells
Effect:
Stimulates differentiation of B cells
Induces fever
IL-8
Source:
Effect:
Source: Macrophages
Effect: Neutrophil chemotaxis
IL-10 (human cytokine synthesis inhibitory factor):
Source:
Effect:
Source: Th2 cells
Effect: Inhibits Th1 cytokine production - anti-inflammatory
IL-12
Source:
Effect:
Source: APCs - Dendritic cells, macrophages, B cells
Effect: Activates NK cells and stimulates differentiation of naive T cells (Th0) into Th1 cells
Which cytokines to Th2 cells secrete (4)
involved in mediating humoral (antibody) immunity
e.g. stimulating production of IgE in asthma
secrete IL-4, IL-5, IL-6, IL-10, IL-13
What is the role of IL-1
What is it secreted by
It is secreted mainly by macrophages and monocytes and acts as a costimulator of T cell and B cell proliferation.
Increases the expression of adhesion molecules on the endothelium.
Stimulates the release by the endothelium of vasoactive factors such as PAF, nitric oxide and prostacyclin
Causes vasodilation and increases vascular permeability.
Which cytokines to Th1 cells secrete (3)
Involved in the cell mediated response and delayed (type IV) hypersensitivity
IL2, 3
IFNg
