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Advanced Veterinary Endocrinology > Interleukins > Flashcards

Interleukins Flashcards

1
Q

IL-1 source

A

Macrophages

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2
Q

IL-1 activity

A

lymphocyte activating factor; stem. T cells and APC; B-cell growth and ab production. Promotes hematopoiesis

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3
Q

IL-2 source

A

Activated T cells (MHC I, CD8+)

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4
Q

IL-2 Target: activity

A

T cells: proliferation and differentiation into effector and memory cells; promotes regulatory T cell development, survival, and function
NK cells: proliferation, activation
B cells: proliferation, antibody synthesis (in vitro)

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5
Q

IL - 4 Source

A

CD4+ T cells, (Th2), Mast cells

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6
Q

IL - 4 Target: Activity

A

B cells: isotype switching to IgE
T cells: T H 2 differentiation, proliferation
Macrophages: alternative activation and inhibition of IFN-γ–mediated classical activation
Mast cells: proliferation (in vitro)

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7
Q

IL - 5 source

A

CD4+ T cells (Th2)

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8
Q

IL - 5 Target: activity

A

Eosinophils: activation, increased generation

B cells: proliferation, IgA production (in vitro)

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9
Q

IL - 6 source

A

Macrophages, endothelial cells, T cells

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10
Q

IL - 6 target: activity

A

Liver: synthesis of acute-phase protein
B cells: proliferation of antibody-producing cells.

Induction of fever, synergistic w/ TNFa

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11
Q

IL - 7 source

A

Fibroblasts, bone marrow stromal cells; thymus

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12
Q

IL - 7 target: activity

A

Immature lymphoid progenitors: proliferation of early T and B cell progenitors
T lymphocytes: survival of naive and memory cells

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13
Q

IL - 8 source

A

Macrophages

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14
Q

IL - 8 target: activity

A

chemoattracts neutrophils produced by monocytes and hepatocytes

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15
Q

IL - 9 source

A

CD4+ T cells

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16
Q

IL - 9 target: activity

A

Mast cells, B cells, T cells, and tissue cells: survival and activation

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17
Q

IL-10 source

A

Activated T cells (Th2), b cells, & monocytes - OR - Macrophages and Treg

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18
Q

IL -10 target: activity

A 
cytokine synthesis inhibitory factor; inhibits production of IL-2 and interferon gamma by Th1 -OR-
Macrophages, dendritic cells: inhibition of expression of IL-12, costimulators, and class II MHC
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19
Q

IL - 11 source

A

Bone marrow stromal cells

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20
Q

IL - 11 target: activity

A

Production of platelets

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21
Q

IL-12 source

A

Macrophages, dendritic cells

22
Q

IL -12 target: activity

A

T cells: T H 1 differentiation

NK cells and T cells: IFN-γ synthesis, increased cytotoxic activity

23
Q

IL-13 source

A

CD4 + T cells (T H 2), NKT cells, group 2 innate lymphoid cells, mast cells

24
Q

IL -13 target: activity

A

B cells: isotype switching to IgE
Epithelial cells: increased mucus production
Fibroblasts: increased collagen synthesis
Macrophages: alternative activation

25
IL-15 source
Macrophages, other cell types
26
IL -15 target: activity
NK cells: proliferation | T cells: survival and proliferation of memory CD8 + cells
27
IL-16 source
T cells, mast cells, eosinophils, epithelial cells
28
IL -16 target: activity
CD4 + T cells, monocytes, and eosinophils: chemoattractant
29
IL-17 source
CD4 + T cells (T H 17), group 3 innate lymphoid cells
30
IL -17 target: activity
Endothelial cells: increased chemokine production Macrophages: increased chemokine and cytokine production Epithelial cells: GM-CSF and G-CSF production
31
IL-18 source
Monocytes, macrophages, dendritic cells, Kupffer cells, keratinocytes, chondrocytes, synovial fibroblasts, osteoblasts
32
IL -18 target: activity
NK cells and T cells: IFN-γ synthesis Monocytes: expression of GM-CSF, TNF, IL-1β Neutrophils: activation, cytokine release
33
IL-19 source
Macrophages
34
IL -19 target: activity
Macrophages: stimulates IL-1 and TNF secretion Keratinocytes: proliferation
35
IL-21 source
T H 2 cells, T H 17 cells, T FH cells
36
IL -21 target: activity
B cells: activation, proliferation, differentiation T FH cells: development T H 17 cells: increased generation NK cells: functional maturation
37
IL-23 source
Macrophages, dendritic cells
38
IL -23 target: activity
T cells: differentiation and expansion of T H 17 cells
39
IL-25 source
T cells, mast cells, eosinophils, macrophages, mucosal epithelial cells
40
IL -25 target: activity
T cells and various other cell types: expression of IL-4, IL-5, IL-13
41
IFNa source
Plasmacytoid dendritic cells, macrophages
42
IFNa target: activity
``` All cells: anti-viral state, increased class I MHC expression NK cells: activation ```
43
IFNb source
Fibroblasts, plasmacytoid dendritic cells
44
IFNb source
``` All cells: anti-viral state, increased class I MHC expression NK cells: activation ```
45
IFNgam source
T cells (T H 1, CD8 + T cells), NK cells
46
IFNgam source
``` Macrophages: classical activation (increased microbicidal functions) B cells: isotype switching to opsonizing and complement-fixing IgG subclasses (established in mice) T cells: T H 1 differentiation Various cells: increased expression of class I and class II MHC molecules, increased antigen processing and presentation to T cells ```
47
IL-22 source
Th17 cells
48
IL - 22 target: activity
Epithelial cells: production of defensins, increased barrier function Hepatocytes: survival
49
TNF source
Macrophages, NK cells, T cells
50
TNF target: activity
Endothelial cells: activation (inflammation, coagulation) Neutrophils: activation Hypothalamus: fever Muscle, fat: catabolism (cachexia)
51
TGF - beta (Transforming growth factor) source
T cells (mainly Tregs), macrophages, other cell types
52
TGF - beta target:activity
T cells: inhibition of proliferation and effector functions; differentiation of T H 17 and Treg B cells: inhibition of proliferation; IgA production Macrophages: inhibition of activation; stimulation of angiogenic factors Fibroblasts: increased collagen synthesis

Advanced Veterinary Endocrinology (1 decks)

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