Intercalating agents Flashcards
1
Q
Is Doxorubicin and specific or non specific DNA intercalating agent?
A
Non-specific
2
Q
Doxorubicin induces protein ______ ____ ____.
How does it do this?
A
Associated strand breaks
It traps topoisomerase II that is covalently bound to DNA
3
Q
Define intercalation…
A
Insertion of a flat aromatic molecule between adjacent base pairs of the double helix
4
Q
Selectivity of agents that target cellular processes might be dependent on the level of the associated target protein e.g. topoisomerase I or II so cells with elevated levels of topoisomerase would be _____ susceptible to doxorubicin - enhanced cancer cell selectivity
A
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