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Pre Reg Exam 2020 > Interactions > Flashcards

Interactions Flashcards

1
Q

Finasteride

A

No clinically important side effects

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2
Q

Z drugs (zopiclone and zolpdiem)

A

Enhance the sedative effects of alcohol, antihistamines and benzodiazepines.
Enhance the hypotensive effects of antihypertensives.
Metabolised by CYP450 enzymes

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3
Q

Warfarin

A

Narrow therapeutic index
Metabolised by CYP450 enzymes
Antibiotics increase the anticoagulation by killing the guy flora that synthesise K
NSAIDs

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4
Q

Enzyme inhibitors

A 
Cimetidine 
Isoniazid
Ketoconazole, fluconazole 
Sodium valproate
Ciprofloxacin 
Amiodarone 
SSRIs (fluoxetine) 
Ritonavir
Terbinafine
Diltiazem and verapamil
Macrolides (clairthromycin, erthyromycin)
Omeprazole
Sulphonamides (co-trimoxazole)
Alcohol and grapefruit juice 
Metronidazole
Chloramphenicol
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5
Q

Enzyme inducers

A 
Phenobarbitone 
Rifamcipin
Carbamazepine 
Phenytoin 
Griseofulvin 
Topiramate 
Smoking
Sulphonylureas
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6
Q

What drugs are metabolised by CYP450 enzymes?

A 
ARBs
NSAIDs
Celecoxib
Glimepride and glipizide
Meloxicam
Montlukast
Phenobarbital 
Phenytoin 
Tolbutamide
Warfarin 
Oestrogen 
Progesterone
Digoxin
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Pre Reg Exam 2020 (3 decks)

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