Interactions

Question 1

Zepatier (EBR/GZR)

+ STATINS

Answer 1

may increase [statin] (use lowest dose)

fine with Pravastatin

Question 2

Zepatier (EBR/GZR)

+ EE

Answer 2

none

Question 3

Zepatier (EBR/GZR)

+ omeprazole/H2RAs

Answer 3

none

Question 4

anything

+ CYP inducers

Answer 4

may decrease concentration, don’t use

ex: CBZ, phenytoin, phenobarb, oxcarbamazepine, rifampin, SJW

Question 5

Zepatier (EBR/GZR)

+ Cyclosporine

Answer 5

CONTRAINDICATED

increase [GZR] = increased ALT

Question 6

The one HCV med that interacts with

+ tacrolimus ??

Answer 6

Zepatier (EBR/GZR)

Potential interaction that increases [tac] so monitor tac levels and CrCl

Question 7

The HCV meds CONTRAINDICATED with darunavir (with cobicistat or ritonavir booster)??

Answer 7

Zepatier (EBR/GZR)
and
Mavyret (GLE/PIB)

Question 8

The HCV meds CONTRAINDICATED with boosted atazanavir??

Answer 8

Zepatier (EBR/GZR)
and
Mavyret (GLE/PIB)

Question 9

Only HCV meds NOT CONTRAINDICATED with nevirapine??

Answer 9

Harvoni (LDV/SOF)

Mavyret (GLE/PIB) is questionable

Question 10

Only HCV med that is CONTRAINDICATED with EE?

Answer 10

Mavyret (GLE/PIB)

increased ALT