interactions 1

Question 1

Fluoxetine, paroxetine, or quinidine +codeine or tamoxifen

Answer 1

decreases effectiveness of codeine or tamoxifen

Question 2

digoxin + quinidine, amiodarone orverapamil

Answer 2

Increases digoxin level by 25-100% and risk of bradycardia

Question 3

Grapefruit juice + lovastatin,atorvastatin, or nifedipine

Answer 3

Increases lovastatin, atorvastatin, or nifedipine absorption and effects

Question 4

Itraconazole or gemfibrozil +simvastatin or lovastatin

Answer 4

Reduced metabolism of the statins- increased myopathy

Question 5

Cholestyramine or colestipol +pravastatin or fluvastatin

Answer 5

Reduced absorption of the statins

Question 6

Propranolol + diltiazem or verapamil

Answer 6

Additive bradycardia

Question 7

cyclosporine + rifampin or St. JohnsWort

Answer 7

Decreases cyclosporine levels

Question 8

cyclosporine + erythromycin orketoconazole or diltiazem

Answer 8

Increases cyclosporine levels

Question 9

Theophylline + erythromycin orciprofloxacin

Answer 9

increases theophylline concentration; decreaseserythromycin conc

Question 10

albuterol + propranolol

Answer 10

Decreases bronchodilation (antagonists)

Question 11

Sildenafil + nitrogylcerin or isosorbidedinitrate

Answer 11

Additive hypotension

Question 12

ciprofloxacin + Mg++, Fe++, Ca++,Zn++, Al+++

Answer 12

decreases bioavailability of ciprofloxacin

Question 13

Caffeine + ciprofloxacin

Answer 13

increased caffeine levels and effects

Question 14

oral contraceptives + antibiotics(many)

Answer 14

decreases efficacy of oral contraceptives

Question 15

methotrexate + cotrimoxazole(Bactrim), NSAIDs or ASA

Answer 15

Increases methotrexate concentration

Question 16

Oral contraceptives + smoking

Answer 16

ncreases CV risk (MI, stroke, thromboembolism) in pts>35 y/o

Question 17

warfarin + rifampin

Answer 17

Decreases effectiveness of warfarin

Question 18

Warfarin + miconazole vaginal cream

Answer 18

Increased anticoagulation

Question 19

warfarin + cimetidine, cotrimoxazole,oxandrolone or amiodarone

Answer 19

Increases risk of bleeding

Question 20

warfarin + aspirin or NSAIDS

Answer 20

Increases risk of bleeding

Question 21

Furosemide + NSAIDS

Answer 21

Decreases diuretic effects

Question 22

Rifampin or St. Johns Wort +

nelfinavir, indinavir or ritonavir

Answer 22

Decreased protease inhibitor levels, probably decreasedefficacy and increased chance of resistance

Question 23

clonidine + tricyclic antidepressants

Answer 23

inhibits antihypertensive response to clonidine

Question 24

imipramine + epinephrine

Answer 24

excessive increase in blood pressure

Question 25

allopurinol + azathioprine or 6-mercaptopurine

Answer 25

increases toxicity of azathioprine (6-Mercaptopurine) (increases bioavailability)

Question 26

MAO inhibitors + SSRIs (fluoxetine)

Answer 26

serotonin syndrome

Question 27

MAO inhibitors + pseudoephedrine

Answer 27

Severe hypertension

Question 28

Potassium + ace inhibitors (captopril)or spironolactone

Answer 28

increases potassium levels

Question 29

Thyroid hormone + Ca++ orraloxifene

Answer 29

reduced absorption of thyroid hormone