Inter and Intra Molecular Interactions Flashcards

1
Q

Biochemistry relies on covalent or noncovalent molecular interactions?

A

noncovalent

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2
Q

Is covalent or non-covalent stronger?

A

Covalent

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3
Q

T/F: noncovalent molecules are bigger and not additive

A

F, they’re smaller and additive

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4
Q

Examples of noncovalent interactions:

A
  • charge charge interactions
  • van der waals forces
  • dipole dipole interactions
  • london dispersion forces
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5
Q

Charge charge interactions follow which law?

A

Coulomb’s law

F=k(q1q2/er2)

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6
Q

Common ions in the human body are…

A
  • Ca2+
  • Na+
  • K+
  • Mg2+
  • Cl-
  • HOPO42-
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7
Q

Energy of interaction is the amount of E needed…

A

to separate the two charged particles

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8
Q

Higher the dielectric constant =

A

weaker the interaction between charges

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9
Q

T/F: a salt bridge is the simplest charge-charge interaction

A

T

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10
Q

Dehydration alters

A

H bonding network b/c less water

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11
Q

Net result of dehydration is…

A

increased strength in charge-charge interactions at same distance

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12
Q

Major way ethanol effects charge-charge interactions:

A

contributes to dehydration

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13
Q

Minor way ethanol effects charge-charge interactions:

A
  • high amounts of ethanol would alter the medium, which will strengthen electrostatic interactions
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14
Q

Dehydration would lead to a higher/lower dielectric constant

A

lower

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15
Q

Lower dielectric constant alters ion reactions b/c…

A

oppositely charged ions would have greater attraction and be less available for reactions

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16
Q

H bonds are the interactions between…

A

a covalently bonded H on a donor group and a pair of bonded e- on acceptor group

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17
Q

H bonds are partially…

A

dipole-dipole interaction and covalent

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18
Q

H bonds are important in biochem b/c…

A

of the quantity (a lot)

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19
Q

H bonding stabilizes…

A

structural elements

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20
Q

Permanent dipole dipole interactions results from…

A

differences in electronegativity between atoms

- unequal e- distribution

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21
Q

Induced dipole results when…

A

molecules are near a charge

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22
Q

Dipole dipole has a slight _____ on each end of the molecule

A

charge

23
Q

London dispersion forces is the _____ interaction

A

weakest

24
Q

Van der waals radius is the…

A

effective radius for closest molecular packing

25
Q

T/F: water is the primary solvent for life

A

T

26
Q

Water makes up __ - __ % of total body weight

A

60-75%

27
Q

Water is found in the highest percentages in the…

A
  • brain
  • kidney
  • muscle
  • blood
28
Q

Biological functions of water:

A
  • solvent: used in transport and mobility
  • reactant: for hydrolysis and hydration of = bonds
  • lubricant
  • osmoregulation
  • supports existence of biological ions
  • mediates body temp
29
Q

Properties of water:

A
  • LMW for room temperature liquid
  • H bonds form between water molecules
  • high heat capacity
  • high heat of vaporization
  • less dense when frozen
  • high viscosity
  • cohesive
  • high dielectric constant (ion-dipole interactions)
30
Q

Why does water have a high heat capacity?

A

b/c dipole dipole interactions reduces movement as it absorbs E, therefore cools body

31
Q

Def of heat capacity:

A

of heat units needed to raise the temperature of body by one degree

32
Q

Why does water have a high heat of vaporization?

A

b/c of dipole dipole interactions

- prevents dehydration and decreases body temp

33
Q

Def of high heat of vaporization:

A

amount of E (enthalpy) needed to turn liquid into gas

34
Q

Amphipathic molecules has both:

A

hydrophobic and hydrophilic properties

35
Q

Example of amphipathic molecules are…

A
  • fatty acids
  • lipids
  • detergents (synthetic lipids)
36
Q

Amphipathic molecules make three formations in water:

A
  • monolayer
  • micelles
  • bilayer
37
Q

Arrangement of monolayer?

A

molecules align at the surface of the liquid in a single layer

38
Q

Arrangement of micelles?

A

molecules align in spherical organization with tails facing inward

39
Q

Arrangement of bilayer?

A

molecules align in two layers w/ tails facing inward

- leaves hydrophilic surfaces on both outside and inside

40
Q

What is the clathrate structure?

A

“cage” of water molecules surrounds nonpolar solute

  • create hydrophobic effect
  • decreases entropy
41
Q

Hydrophobic effect stabilizes protein structure by…

A

driving apolar side chains on amino acids together

42
Q

ICF makes up how much of body water?

A

2/3

43
Q

ICF makes up how much of body weight?

A

40%

44
Q

ICF is a solution made up of…

A

K+, organic anions, and proteins

45
Q

T/F: ICF is homogeneous in body

A

F

46
Q

What controls the constituents of ICF?

A

metabolism and cell membranes

47
Q

ECF makes up how much of body water?

A

1/3

48
Q

ECF makes up how much body weight?

A

20%

49
Q

ECF is a solution made up of…

A

NaCl and NaHCO3

50
Q

ECF has three subcompartments:

A
  • ISF: surrounds cells
  • plasma: circulates as extracellular component of blood
  • transcellular fluid: outside normal compartments
51
Q

T/F: fluid compartments are not in osmotic equilibrium

A

F

52
Q

Osmotic pressure:

A

hydrostatic pressure produced by a solution in a space decided by a semipermeable membrane due to differential in [ ] of solute

53
Q

Osmole:

A

non-SI unit of measurement that defines the # of moles of a chemical compound that contributes to osmotic pressure

54
Q

Osmolality:

A

measure of osmoles of solute/kg of solvent