Integumentary Diseases and Drugs Flashcards

1
Q

Ketoconazole ( Nizoral)

A

controls itching, scaling associated with dandruff, antifungal (shampoo)

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1
Q

Tacrolimus

A

atopic dermatitis/perioral dermatitis/mild psoriasis, topical calcineurin inhibitor (ointment) [0.03% for 2 yrs and above = grp 4-5 TCS] [0.1% for 16 yrs and above = grp 4 TCS]

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2
Q

Pimecrolimus

A

atopic dermatitis/perioral dermatitis/mild psoriasis, topical calcineurin inhibitor (cream) [1% for 3 mths and above = grp 6 TCS]

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3
Q

Crisaborole

A

atopic dermatitis, topical phosphodiesterase 4 inhibitor [2% ointment]

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4
Q

Ruxolitinib (Not HSA approved)

A

atopic dermatitis, JAK inhibitor, tablet [short term use only] *max dose 60g/week or 100g/2 weeks

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5
Q

Topical corticosteroids (examples and classes in separate deck)

A

atopic dermatitis/mild-mod psoriasis, TCS (be careful for withdrawal symptoms) *if using class 1/2 high potency TCS–> maximum 2-4 weeks of usage (many cutaneous and systemic side effects)

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6
Q

Dupilumab

A

severe AD that does not respond to topical treatment, Biologic/IL-4/13 antagonist, SC injection

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7
Q

Cyclosporine (oral)

A

severe AD/severe psoriasis, immunosuppressant

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8
Q

Azathioprine (oral)

A

severe AD, immunosuppressant

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9
Q

Abrocitinib

A

severe AD that does not respond to topical treatment, biologics and other systemic drugs, JAK inhibitor

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10
Q

Upadacitinib

A

severe AD that does not respond to topical treatment, biologics and other systemic drugs, JAK inhibitor

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11
Q

Chlorpheniramine

A

secondary infections from AD, oral antihistamine

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12
Q

Flucloxacillin

A

secondary bacterial infections from AD (due to excoriated skin), antibiotic

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13
Q

Acyclovir

A

secondary viral infections from AD/ Herpes Labialis, antiviral

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14
Q

Hydrocortisone

A

AD/ACD/ICD, TCS

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15
Q

Clobetasone

A

ACD/ICD, TCS

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16
Q

Ivermectin (Oral)

A

Scabies, Anthelmintic

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17
Q

Isotretinoin (Oral)

A

severe AV/ acne conglobata, retinoic acid derivative that targets sebaceous glands. (teratogenic, dry eyes, sun-sensitivity [use of sunscreen], depression/suicidal]

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18
Q

Adapalene

A

AV, topical retinoid (1st choice therapy)

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19
Q

Tretinoin

A

AV, topical retinoid (teratogenic and sun-sensitivity)

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20
Q

Tarazotene

A

AV, topical retinoid (teratogenic and sun-sensitivity)

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21
Q

Benzoyl Peroxide

A

AV, antimicrobial/anti-inflammatory/anti-comedonal (will cause erythema and xerosis but continue usage) (usually used in combined therapy with retinoids/oral antibiotics)

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22
Q

salicylic acid

A

AV/mild-mod psoriasis, exfoliant and has keratolytic propertis (not very safe and efficaceous for AV) *cannot be used with phototherapy and Vit D analogues

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23
Q

Azelaic acid

A

mild-mod AV, comolytic/antibacterial/ anti-inflammatory agent

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24
Q

Clindamycin

A

AV, topical antibiotic (not recommended for mono-therapy due to possible antibiotic resistance) (used tgt with Benzoyl peroxide)

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25
Q

erythromycin (oral)

A

AV, oral antibiotics (safe in pregnant women)

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26
Q

tetracycline

A

AV, oral antibiotics (teratogenic, sun-sensitive and should not be used alone due to possible antibiotic resistance) (used with concurrent topical therapy)

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27
Q

doxycycline

A

AV, oral antibiotics (teratogenic, sun-sensitive and should not be used alone due to possible antibiotic resistance) (used with concurrent topical therapy)

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28
Q

minocycline

A

AV, oral antibiotics (teratogenic, sun-sensitive and should not be used alone due to possible antibiotic resistance) (used with concurrent topical therapy)

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29
Q

cyproterone acetate with ethinyl estradiol

A

for long term AV in women, hormonal therapy with oral contraceptive (anti-androgenic properties)

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30
Q

erythromycin (topical)

A

perioral dermatitis, topical antibiotic

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31
Q

oxymetazoline (topical)

A

rosacea, alpha adrenergic agonist

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32
Q

brimonidine (topical)

A

rosacea, alpha adrenergic agonist

33
Q

mupirocin

A

Impetigo, topical antibiotic (kills methicillin resistant S.aureus)

34
Q

retapamulin

A

Impetigo, topical antibiotic

35
Q

topical fusidic acid (Fucidin)

A

Impetigo, topical antibiotic (increasing resistance to S.aureus)

36
Q

Ozenoxacin

A

Impetigo, topical antibiotic/quinolone

37
Q

Miconazole (topical)

A

angular cheilitis/tinea infections not including tinea capitis, antifungal

38
Q

Kenacomb: neomycin, gramicidin, nystatin, triamcinolone acetonide

A

angular cheilitis, hybrid antifungal and antibacterial

39
Q

Trifarotene

A

truncal acne, topical retinoid

40
Q

Itraconazole (oral)

A

tinea infections including tinea capitis, oral antifungal

41
Q

Fluconazole (oral)

A

tinea infections including tinea capitis, oral antifungal

42
Q

Terbinafine (oral)

A

tinea infections including tinea capitis/gold standard treatment for onychomycosis, oral antifungal (effective in preventing recurrence)

43
Q

Griseofulvin (oral)

A

tinea capitis caused by M.audouinii, oral antifungal

44
Q

Ketoconazole (oral)/(topical)

A

tinea infections/seborrheic dermatitis(topical only), antifungal

45
Q

clotrimazole (topical)

A

tinea infections not including tinea capitis, topical antifungal

46
Q

Isoconazole (topical)

A

tinea infections not including tinea capitis, topical antifungal

47
Q

sertaconazole (topical)

A

tinea infections not including tinea capitis, topical antifungal

48
Q

Itraconazole (pulse therapy)

A

Onychomycosis, anti fungal

49
Q

Amorolfine

A

Onychomycosis, anti fungal

50
Q

Ciclosporax (not HSA approved)

A

Onychomycosis, hydroxypyridone derivative

51
Q

Tavaborole (not HSA approved)

A

Onychomycosis, anti fungal

52
Q

Calcitriol

A

mild-mod psoriasis, Vit D analogue (inactivated by salicylic acid)

53
Q

Calcipotriol

A

mild-mod psoriasis, Vit D analogue (inactivated by salicylic acid)

54
Q

tacaltriol

A

mild-mod psoriasis, Vit D analogue (inactivated by salicylic acid)

55
Q

Coal tar

A

mild-mod psoriasis

56
Q

PUVA/UVB phototherapy

A

moderate psoriasis

57
Q

acitretin

A

mod-severe psoriasis, oral retinoid (teratogenic and need to avoid ethanol)

58
Q

apremilast

A

mod-severe psoriasis, oral phosphodiesterase 4 inhibitor

59
Q

methotrexate

A

severe AD/mod-severe psoriasis, oral immunosuppressant

60
Q

etanercept

A

mod-severe psoriasis, biologic (TNF-alpha inhibitor)

61
Q

infliximab

A

mod-severe psoriasis, biologic (TNF-alpha inhibitor)

62
Q

adalimumab

A

mod-severe psoriasis, biologic (TNF-alpha inhibitor)

63
Q

certolizumab

A

mod-severe psoriasis, biologic (TNF-alpha inhibitor)

64
Q

secukinumab

A

mod-severe psoriasis, biologic (IL-17 inhibitor)

65
Q

ixekizumab

A

mod-severe psoriasis, biologic (IL-17 inhibitor)

66
Q

brodalumab

A

mod-severe psoriasis, biologic (IL-17 inhibitor)

67
Q

guselekumab

A

mod-severe psoriasis, biologic (IL-23 inhibitor)

68
Q

tildrakizumab

A

mod-severe psoriasis, biologic (IL-23 inhibitor)

69
Q

risankizumab

A

mod-severe psoriasis, biologic (IL-23 inhibitor)

70
Q

tofacitinib

A

severe psoriasis, JAK inhibitor

71
Q

minoxidil

A

androgenetic alopecia/alopecia areata, topical skin product

72
Q

finasteride

A

androgenetic alopecia, 5-alpha reductase inhibitor (for men only)

73
Q

Triamcinolone acetonide injection

A

alopecia areata, corticosteroid (injected intradermally)

74
Q

Octinoxate

A

organic filter in sunscreen, Cinnamate (UVB)

75
Q

Octocrylene

A

organic filter in sunscreen, (UVB)

76
Q

Oxybenzone

A

organic filter in sunscreen, benzophenone (UVB, UVA2)

77
Q

Avobenzone

A

organic filter in sunscreen, benzophenone (UVA1)

78
Q

ZnO

A

inorganic filter in sunscreen

79
Q

TiO2

A

inorganic filter in sunscreen