integration of metabolism Flashcards
1
Q
what is happening in the fed state?
A
- hepatic portal vein transports nutrients from the liver to tissues
- glycogen stores are created, nutrients are distributed
2
Q
what processes occur in the liver during the fed state?
A
- increased phosphorylation of glucose
- increased glycogen synthesis
- increased pathway of the pentose phosphate pathway
- increased rate of glycolysis
- increased fatty acid synthesis
3
Q
what occurs in the adipose in the fed state?
A
- increased glucose uptake
- increased rate of glycolysis
- increased activity of PPP
- increased supply of chylomicrons
- increased TAG synthesis
4
Q
what is the fasted state?
A
catabolic state that begins if no further fuel is ingested after the fed state. involves the use of fuel reserves
5
Q
what is the regulatory molecule of the fasted and fed states?
A
fasted - glucagon
fed - insulin
6
Q
what occurs in the liver in the fasted state?
A
- increased rate of glycogen degradation
- increased rate of gluconeogenesis
- increased rate of fatty acid oxidation
- production of ketone bodies
7
Q
what occurs in the adipose tissue in the fasted state?
A
- increased degradation of TAGs
- increased release of fatty acids
8
Q
what are the complications of type I diabetes?
A
- hyperglycaemia
- ketoacidosis
- hypertriacylglycerolaemia
9
Q
why is blood glucose high in type I diabetes?
A
the body thinks its in a fasted state due to the absence of insulin, so it makes glucose via gluconeogenesis, leaving extra glucose in the blood
