Integration of Metabolism

Question 1

What are the three fuel storages of the heart?

Answer 1

Fatty Acids

Lactate

Ketone Bodies

Question 2

What percentage of the total body weight is brain and nervous tissue?

Answer 2

2%

Question 3

What is adipose tissue?

Answer 3

Long term storage site for fatty acids in the form of triglycerides

Question 4

What are carbohydrates broken down into?

Answer 4

Simple sugars

Question 5

What happens to pyruvate before it becomes acetyl CoA?

Answer 5

It is reduced and decarboxylated

Question 6

Where in the body can excess G6P be used to generate glycogen?

Answer 6

Liver and muscle

Question 7

What can excess acetyl CoA be used to generate?

Answer 7

Fatty acids

Question 8

What and where are fatty acids stored?

Answer 8

They are stored as triglycerides in adipose tissue

Question 9

What is produced during extreme exercise?

Answer 9

Lactic acid

Question 10

What is the brain largely dependent on as a metabolic fuel?

Answer 10

Glucose

Question 11

What is the definition of hypoglycaemia?

Answer 11

Plasma glucose level falling below 3mM

Question 12

List 3 ways the body can avoid hypoglycaemia?

Answer 12

1. Breakdown of liver glycogen stores occurs to maintain plasma glucose levels
2. Release free FAs from adipose tissue
3. Convert acetyl CoA into ketone bodies via the liver

Question 13

What is the overall aim of gluconeogenesis?

Answer 13

To generate glucose from pyruvate

Question 14

What is the Cori cycle?

Answer 14

When lactate is taken up by the liver and utilised to regenerate pyruvate by Lactate Dehydrogenase

Question 15

What are the products of triglyceride hydrolysis?

Answer 15

FAs and glycerol