insulin therapy

Question 1

what are the anabolic effects of insulin

Answer 1

increase syn, and reduce degradation of glycogen, lipids, and protiens

Question 2

what are the mitogenic functions of insulin

Answer 2

initiation of DNA synthesis in cells and stimulation od growth and differentiation

Question 3

what stimulates the release of insulin

Answer 3

rise in serum glucose levels

Question 4

where is insulin derived

Answer 4

from pre(pro) insulin in the beta cells of pancreas

Question 5

Dx of metabolic syndrome

Answer 5

• waist circumference: >40 in mlaes >35 in fem.
• HTN: >130/>85
  -Serum glucose : >110
  serum TG: >150
  serum HDL: < 40 m <50 F

Question 6

what does glucose syn in adipocytes?

Answer 6

glycerol, which is then used to synthesize triglycerides

Question 7

Insulin therapy

Answer 7

• replacement is required for survival of all type 1

Question 8

when is insulin used in type 2 DM

Answer 8

when diet and exercise and the oral hypoglycemic agents have failed to restore adequate glucose control

Question 9

how is insulin classified?

Answer 9

time of onset and duration of action

Question 10

rapid acting insulin

Answer 10

Lispro/aspart
Humulog/novalog

onset:

Question 11

Short acting

Answer 11

Rugular
Humulin R

Onset: .5-1 hr
duration :4-6 hr

Question 12

intermediat acting

Answer 12

NPH
Humulin N

onset: 1-3 hr
duration: 12-18

Question 13

long acting

Answer 13

glargine
lantus

onset 4-6 hrs
duration: 24

Question 14

dosing of insulin

Answer 14

.4-.06 units per Kg is the typical requirement.

this is divided into
doses to approximate normal post prandial insuin peaks and basal insulin release

• common: combination of NPH and Regualr insulin admin before breakfast and before dinner

Question 15

ultraLente and lantus

Answer 15

coverage during sleep hours