Insulin Resistance Flashcards
What are the functions of insulin?
How does insulin resistance contribute to Alzheimer’s Disease?
How does insulin resistance contribute towards heart failure?
What are risk factors of insulin resistance?
No symptoms
Overweight, physically inactive, family history of diabetes, genetics, polycystic ovary syndrome (PCOS), gestational diabetes, high BP, low HDL, high blood triglyceride, heart disease, smoking
What is the mechanism of insulin resistance in skeletal muscle cells?
What is the mechanism of insulin resistance/inflammation in liver cells?
How does hepatic insulin resistance manifest?
What is the gold-standard for measuring insulin sensitivity?
The hyperinsulinemic-euglycemic clamp
Constant insulin infusion, variable glucose infusion needed depending on sensitivity
What are the various insulin sensitivity index?
How can insulin resistance be reversed?
Eat less
Move more
Medication: metformin/thia
How does metformin lower liver production of glucose?
Reduced gluconeogenesis, in stead of reducing glycolysis (kind of not affecting glycolysis)
