Insomnia Lecture Flashcards

1
Q

Types of insomnia

A

Difficulty falling asleep (sleep onset)
Difficulty maintaining sleep (sleep maintenance)
Early morning awakening (sleep offset)
Unrefreshing sleep (non-restorative sleep)

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2
Q

Insomnia facts?

A

33% experience insomnia
$14 billon on medical costs
$325.8 million nonprescription meds
Prevalence increases with age and with women
26% try natural products
5X more likely to present with anxiety and or depression
Can be due to another medical disorder

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3
Q

Classification of insomnia

A

Transient
Short-term
Chronic

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4
Q

Define transient

A

Self-limiting
<1 week
Travel, hospitalization or upcoming stress

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5
Q

Define short-term

A

1-3 weeks

More serious stressor (death, unemployment, divorce)

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6
Q

Define chronic

A

Almost every night for >3 weeks

Result of an underlying cause

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7
Q

Define insomnia disorder

A
  • Predominant complaint of dissatisfaction with sleep quantity/quality associated with one or more: difficulty initiating sleep, maintaining, early-morning awakenings
  • Sleep disturbances causes clinically significant distress or impairment in other parts of the life
  • More than 3 nights per week
  • At least 3 months
  • Difficulty occurs even when sleep is an option
  • No other explanation
  • Not attributable to physiological effects of substance <drug abuse, alcohol, etc)
  • No other coexisting mental disorder or conditions
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8
Q

Define situational/acute insomnia

A

Last a few days/weeks, associated with life events or rapid changes in sleep/environment

  • Daytime napping
  • Activity before sleep (eating and exercise)
  • Jet lag
  • Sift work
  • Stress
  • Poor sleep hygiene
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9
Q

Medications of insomnia?

A
Albuterol
Anti (depressants, psychotics, convulsants, parkinson's)
Alcohol
Nicotine
Decongestants
Theophylline
Steroids
Stimulants (caffeine, amphetamines)
Clonidine
Methyldopa
Beta blockers
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10
Q

What are complications of sleep disorders?

A
Worsening health (depression, headaches, heart disease)
Substance abuse
Daytime drowsiness
Decreased productivity
Car accidents
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11
Q

Signs and symptoms of insomnia?

A
Complaint of difficulty falling or staying asleep
Daytime fatigue
Poor concentration
Impaired memory
Irritability
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12
Q

Assessment of insomnia?

A

Consider: symptoms, onset, duration, severity, history, pre-sleep conditions, sleep schedule, daytime functioning, drug or substance abuse

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13
Q

What are supportive of insomnia?

A

Do you take longer than 30 minutes to fall asleep?
Wake up and stay awake for more than 30 minutes
Sleep less than 50% of the time you are in bed
Less than 6.5 hours
Falling asleep at work or at school?

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14
Q

What are exclusions for self treatment of insomnia?

A

Less than 12 or older than 65
Pregnant
Nocturnal awakenings or early morning awakening
Chronic insomnia
Sleep disturbances at night for several days
Secondary to a other medical disorders (sleep apnea, narcolepsy, restless leg syndrome)

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15
Q

What are goals of treatment?

A
Alleviate symptoms
Minimize adverse effects
Improve quality of life and function
Id and address cause of insomnia
Outcomes: decreased time to fall asleep, sleep quality, decrease daytime fatigue and drowsiness, normal sleep cycle
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16
Q

What is cognitive behavioral therapy?

A
Stimulus control
Sleep restriction
Relaxation
Cognitive therapy
Sleep hygience
Session for 4-6 weeks
Few of the above at a time
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17
Q

Preferred non-pharmacological therapies?

A

Try to ID the cause
Evidence shows CBT works and is safe
Improves sleep over time
Try before initiating pharmacotherapy

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18
Q

What does good sleep hygiene mean?

A
Stick to a schedule
Exercise regularly
Turn off worries
Make bedroom quiet, dark, safe and comfortable
Not too cold or hot
No large meals before bed
Not lots of food before bed
Do not read or watch tv in bed
-- Sleep and sexual activity only
If you can't sleep, get up after 10 minutes
Remove the clock
Avoid or limit daytime naps
Reduce alcohol, nicotine and caffeine use
Avoid using sedatives frequently
19
Q

Antihistamines drug products?

A

Diphenhydramine- Benadryl
Doxylamine- Unisome, Nyquil
– often contain acetaminophen or ibuprofen

20
Q

Antihistamines drug MOA?

A

Ethanolamine antihistamine
Block histamine 1 and muscarinic receptors
Newer are less lipophilic exert few CNS effects

21
Q

Antihistamines drug adverse effects?

A
Sedation
Morning hangover effect
Dry mouth/throat
Constipation 
Blurred vision
Urinary retention 
Diminished cognitive function
22
Q

Antihistamines drug reactions?

A

Anticholinergic meds

CYP450 2D6

23
Q

Antihistamines drug precautions/contraindications?

A
Males of advanced age
Angle closure glaucoma
Dementia
Cardiovascular disease
Prolonged half-life  with cirrhosis
24
Q

Antihistamines drug conseling?

A

May develope tolerance
Use cation in tasks that require alertness
Do not drink alcohol
Paradoxical effects

25
Q

How does alcohol affect insomnia?

A

Improves sleep in nonalcoholics
Tolerance develops quickly
Chronic drinkers have disturbed sleep cycles
Experience: fall asleep faster, more restless, wake up after 2-4 hrs, reduces total sleep time

26
Q

Define complementary therapy?

A

May promote health and relaxation
58% of patients do not discuss use of complementary therapy with their PCP
Complementary therapies include: acupuncture, music therapy, light therapy, herbs and natural products

27
Q

Valerian indications and MOA?

A

Most studied
Benzodiazepine-like effects
Increase GABA activity in CNS by inhibiting an enzyme that metabolizes GABA

28
Q

Valerian clinical effects?

A

Reduce time to sleep onset

Take several nights to weeks to work

29
Q

Valerian adverse effects?

A

Headache, excitability, paradoxical insomnia

Cause uterine contractions in pregnant women

30
Q

Valerian precautions?

A

Few cases of hepatotoxicity

Interactions possible with CYP450 3A4

31
Q

Melatonin MOA?

A

Increases endogenous production by pineal gland

May allow for rapid adjustment of circadian rhythm after changing time zones

32
Q

Melatonin clinical effects?

A

Evidence for jet lag
Increase REM, decrease latency
Low risk of dependence or abuse

33
Q

Melatonin adverse effects and precautions?

A

headache, tachycardia, irritability, “hangover”
Do not use in pregnancy or lactaion
No elderly
Drug interactions

34
Q

Define german chamomile

A

Bedtime tea –> takes time to work
May affect GABA receptors
May be beneficial in patients with anxiety
May interact with CYP450 3A4
Avoid in patients with ragweed or similar allergies

35
Q

Define passionflower

A

Once was an OTC sleep aid
Now a dietary supplement
May cause sedation by affecting benzodiazepine receptors
No evidence

36
Q

Define KAVA

A

Efficacy: insufficient evidence
Safety: possibly unsafe due to severe hepatotoxicity
NOT APPROVED FOR INSOMNIA

37
Q

Define L-tryptophan

A

Efficacy: insufficient evidence
Safety: possibly unsafe –> recalled
NOT APPROVED FOR INSOMNIA

38
Q

Define 5-HTP

A

Efficacy: insufficient evidence
Possibly unsafe
NOT APPROVED FOR INSOMNIA

39
Q

Define coenzyme Q-10

A

Efficacy: possibly effective
Safety: likely safe
Bottom line: helps with insomnia due to heart failure, discuss with physician first

40
Q

Insomnia in elderly

A
Duration of sleep is shorter
# of nocturnal awakenings increases
Less time in stage 4 and REM sleep 
Normal sleep latency
Diphenhydramine can cause increased cognitive impairment and falls
41
Q

Insomnia in children

A

Asked about caffeine and alcohol intake
Nonpharmacologic therapy first line
Anthistamines not indicated to treat insomnia in less than 12 years old
Not recommended to induce sleep in infants
Use of melatonin is controversial

42
Q

Insomnia in pregnancy?

A

Diphenhydramine Category B
Should be referred for evaluation
Herbals not recmmended

43
Q

Insomnia in lactating women?

A

May limit lactation
Increase infant drowsiness
Herbals not recommnded