Innate Immunity Revisited in FW3F

Question 1

Natural Killer cells are lymphocytes that monitor the expression of which MHC Class?

Answer 1

Class I

total levels, not specific peptides

Question 2

Activation of Natural Killer cells requires what two signals?

Answer 2

• decreased MHC class I (many viruses inhibit class I expression)
• activating ligand/receptor (stress-induced)
• ->infection upregulates such ligands

Question 3

Natural Killer cells kill cells in similar fashion to what other cell?

Answer 3

CD8 T cells