Innate Immunity-Ravichandran Flashcards
1
Q
What are 3 effects of complement activation?
A
Recruitment of inflammatory cells, opsonization of pathogens and killing of pathogens
2
Q
What does IL-6 produced by bacteria induced macrophages act on?
A
Hepatocytes to induce synthesis of acute-phase proteins
3
Q
What are 2 acute-phase proteins produced by hepatocytes?
A
C-reactive proteins and mannan-binding lectin
4
Q
What do C-reactive proteins bind and do?
A
Bind phosphorylcholine on bacterial surfaces, acting as an opsonin and also activating complement
5
Q
What does mannan-binding lectin bind and do?
A
Binds mannose residues on bacterial surfaces, acting as an opsonin and also activating complement
