Innate Immunity Flashcards
1
Q
what are the professional phagocytes?
A
- PMNs (neutrophils
- macrophages
2
Q
what are the cytokines that take part in the innate immune mechanisms?
A
- INF beta, INF alpha
- IL-1
- IL-6
- IL-12
- TNF alpha
- chemokines - IL-8
3
Q
which cells are the main producers of cytokines?
A
macrophages and dendritic cells
- exception is keratinocytes which also produce IL-1
4
Q
IL-1 effect
A
- induces acute phase protein secretion
- “hot” in Hot TBone stEAK
5
Q
IL-6 effect
A
- induces acute phase protein secretion
- T in hot Tbone steak
6
Q
IL-8
A
- chemoattractant for neutrophils
7
Q
IL-12
A
- proinflammatory
- cytokine secretion
- diverts responses to Type 1
8
Q
TNF-alpha
A
- induces changes to vascular endothelium
- causes leukocyte recruitment
9
Q
Interferon Alpha & Beta
A
- INTERFERS with viruses
- activates NK cells
- increase MHC 1
10
Q
What produces INF A and B
A
- fibroblasts, epithelial cells, NK cells
11
Q
TNF alpha
A
animal model Schwartzman reaction
12
Q
chemokines examples
A
- CXCL8
- Macrophage Chemotactic Protein (MCP)
- MIP-1alpha
13
Q
acute phase proteins released by hepatocytes
A
- C reactive protein (CRP) - acts as non-specific opsonin
- mannose binding lectin (MBL)
- fibrinogen
- alpha-macroglobulin
14
Q
what cytokines mediate fever?
A
- IL-1
- IL-6
- TNF
15
Q
IL-3 and IL-7
A
- colony stimulating factors
- macrophage-, granulocyte- colony stimulating factor