Innate Immunity Flashcards

1
Q

what are the professional phagocytes?

A
  • PMNs (neutrophils

- macrophages

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2
Q

what are the cytokines that take part in the innate immune mechanisms?

A
  • INF beta, INF alpha
  • IL-1
  • IL-6
  • IL-12
  • TNF alpha
  • chemokines - IL-8
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3
Q

which cells are the main producers of cytokines?

A

macrophages and dendritic cells

- exception is keratinocytes which also produce IL-1

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4
Q

IL-1 effect

A
  • induces acute phase protein secretion

- “hot” in Hot TBone stEAK

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5
Q

IL-6 effect

A
  • induces acute phase protein secretion

- T in hot Tbone steak

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6
Q

IL-8

A
  • chemoattractant for neutrophils
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7
Q

IL-12

A
  • proinflammatory
  • cytokine secretion
  • diverts responses to Type 1
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8
Q

TNF-alpha

A
  • induces changes to vascular endothelium

- causes leukocyte recruitment

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9
Q

Interferon Alpha & Beta

A
  • INTERFERS with viruses
  • activates NK cells
  • increase MHC 1
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10
Q

What produces INF A and B

A
  • fibroblasts, epithelial cells, NK cells
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11
Q

TNF alpha

A

animal model Schwartzman reaction

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12
Q

chemokines examples

A
  • CXCL8
  • Macrophage Chemotactic Protein (MCP)
  • MIP-1alpha
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13
Q

acute phase proteins released by hepatocytes

A
  • C reactive protein (CRP) - acts as non-specific opsonin
  • mannose binding lectin (MBL)
  • fibrinogen
  • alpha-macroglobulin
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14
Q

what cytokines mediate fever?

A
  • IL-1
  • IL-6
  • TNF
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15
Q

IL-3 and IL-7

A
  • colony stimulating factors

- macrophage-, granulocyte- colony stimulating factor

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