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Med 3 Immunology > Innate Immunity > Flashcards

Innate Immunity Flashcards

1
Q

Antimicrobial peptides - Defensins

A

Produced by neutrophils, NK cells, cytotoxic T cells

Alpha defensins: skin
Beta defensins: resp. epithelium
Paneth cells: produce crytpcidins

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2
Q

Antimicrobial peptides - Cathelicdins:

A

Produced by epithelia and neutrophils

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3
Q

IL-1

A

Activates vascular endothelium (Sticky for PMNS) and lymphocytes
Local tissue destruction
Increase access of effector cells
*INDUCES PRODUCTION OF IL-6 (acute phase reactants)

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4
Q

TNF-alpha

A

Increases vascular endothelium, fever, shock

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5
Q

*IL-6

A

Produced from IL-1
Lymphocyte activation
Increased antibody production

Fever
Induces acute-phase protein production

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6
Q

IL-8 (CXCL8)

A

Chemotactic factor that attracts/recruits PMNs, basophils, T cells to site of infection

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7
Q

IL-12

A

ACTIVATES NK cells
Induces differentiation of CD4 TH cells into
TH1 and TH3

TH1 - take care of intracellular infections
TH2 - required for switching abs

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8
Q

LAD -1

A

Defect in CD 18 (Beta integrin)

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9
Q

LAD-2

A

Defect in Sialyl-Lewis molecule

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Med 3 Immunology (4 decks)

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