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FS2 > Innate Immunity > Flashcards

Innate Immunity Flashcards

1
Q

IL1Beta

A

Pro inflammatory cytokine

Activates vascular endothelium

Activated by Caspase-1,as part of inflammasome

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2
Q

TNFAlpha

A

Pro inflammatory cytokine

Activates endothelium, vascular permeability

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3
Q

IL6

A

Pro inflammatory cytokine

Lymphocyte activation

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4
Q

IL8

A

Chemotactic cytokine

Recruit neutrophils

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5
Q

IL12

A

cytokine

Activate NK Cells
Cause differentiarion of T cells into Th1

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6
Q

TLR1,2,6

A

Toll like receptor
Cell wall components

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7
Q

TLR4

A

Toll like receptor
LPS

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8
Q

TLR5

A

Toll like receptor
Flagellin

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9
Q

TLR3 7,8,9

A

Toll like receptor
Detect nuclear components like virual or bacterial dna

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10
Q

DAMPs examples

A

DAMPs= Damage associated molecular protein

Nucleic acids
Histone proteins
Heat shock proteins

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11
Q

Soluble recognition molecules (PRMs)

A

Ante-antibodies

Pentraxins collectins ficolins

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12
Q

PMN vs APC

A

PMN =polymorphonuclear lymphocytes = Neutrophils, many but shortlived

Progessional APCs = longer lived, fewer

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13
Q

Emergency grandulopoeisis

A

Need many neutrophils for systemic infection

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14
Q

Rolling mechanism, and regularion

A

Selectins on epithelial cells bind to PSGL on neutrophils

Regulared by pentraxin-3 (PTX3)

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15
Q

Activation of neutrophils, and regulation

A

Neutrophils activated by chemokines

Reduced by GDF15, prevent LFA1 expression

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16
Q

Firm adhesion of neutrophils, and regulation

A

Firm adhesion: LFA1 on neutrophils bind to ICAMs

Regulation by DEL1

17
Q

ILC 1

A

ILC1 mess with intracellular bacteria and viruses and parasites

IFN Gamma

18
Q

ILC2

A

Helminths

IL4, 5, 13

19
Q

ILC3

A

Extracellular bacteria, fungi

IL17 and 22

20
Q

Interferon types

A

Type 1 or alpha/beta made bymost cells

Type 2 or gamma made by lymphocytes

Made in response to viral infections, cause AVP production

21
Q

Inflammasome components

A

Cytosolic PRR, (NLR or ALR) detect DAMPs and PAMPs

Adapter protein (ASC)

Pro-Caspase-1, which is the inactive form. Becomes caspase 1 when MAMPs/DAMPs are present

22
Q

Th1

A

Made from IFNgamma, IL12
Makes IFNgamma
Activates macrophages

23
Q

Th2

A

Made from IL4,13

Makes IL4,5
Helminths (eosinophil and mast cell activation)

24
Q

Th17

A

Made from IL6,21, and TGFbeta
Makes IL17,22
Neutrophil recruitment and activation

25
Q

How to class switch to IgG

A

Expose b cell to IFNgamma

26
Q

How to class switch to IgE

A

Expose b cell to IL4

27
Q

How to class witch to IgA

A

Expose b cell to TGFbeta

FS2 (2 decks)

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