Innate Immune system

Question 1

What is the activated function of Macrophage cell

Answer 1

Phagocytosis and activation of bactericidal mechanisms

Antigen presentation

Question 2

Discovery of Phagocytosis

Answer 2

1882 Discovery of Phagocytosis starfish larvae
1908 Shared Nobel prize in physiology and medicine with Paul Ehrlich
Established concept of cell mediated immunity, while Ehrlich established the concept of humoral immunity

Question 3

What is the activated function of the dendritic cell ?

Answer 3

Antigen uptake in peripheral sites

Antigen presentation

Question 4

What is the activated function of neutrophil cell?

Answer 4

Phagoctyotosis and activation of bactericidal mechanisms

Question 5

Further functions of neutrophils?

Answer 5

Phagocytic like macrophages
Kill pathogens by oxidative burst and release of granules
Release of DNA nets (Netosis)

Question 6

What is the activated function of Eosinophil cell?

Answer 6

Killing of antibody - coated parasites

Question 7

What is the activated function of basophil cell ?

Answer 7

Promotion of allergic responses and augmentation of anti-parasitic immunity

Question 8

What is the activated function of the Mast cell?

Answer 8

Release of granules. containing histamine and active agents

Question 9

What are cytokines?

Answer 9

Small protein messengers that coordinate the immune response

Question 10

Sensing Danger

Answer 10

Tol - like receptors

Development role

Question 11

Consequence of TLR signalling

Answer 11

Modulate cell function
Cytokine secretion
Chemokine secretion