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'2B1 > Innate herkenning (humoraal en cellulair) > Flashcards

Innate herkenning (humoraal en cellulair) Flashcards

1
Q

C1q

A

Herkent en activeert klassieke route

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2
Q

C3b

A

Opsoniseert en activeert alternatieve route

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3
Q

C5a

A

Chemotaxie, productie ROS en NO, meer Fc- en C-receptoren
Anafylatoxinen, degranuleert mestcellen, vasoactieve stoffen, contractie glad spierweefsel, verhoogde vasculaire permeabiliteit

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4
Q

C3a

A

Anafylatoxinen, degranuleert mestcellen, vasoactieve stoffen, contractie glad spierweefsel, verhoogde vasculaire permeabiliteit

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5
Q

C4a

A

Anafylatoxinen, degranuleert mestcellen, vasoactieve stoffen, contractie glad spierweefsel, verhoogde vasculaire permeabiliteit

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6
Q

C5b-C9

A

Membrane Attack Complex, lysis

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7
Q

Klassieke complement route

A

C1q+C1r+C1s bindt antilichaam, splitsing C2 C4, C2aC4b –> C3 convertase

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8
Q

Lectine route

A

MBl bindt glycaan, splitsing C2 C4 –> C2aC4b –> C3 convertase

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9
Q

Alternatieve route

A

Spontane depositie C3, factor B –> factor Bb –> C3bBb = C3 convertase

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10
Q

SPA, SPD

A

Collectines, stimuleren macrofagen door opsonisatie pathogenen

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11
Q

Ficoline-1, -2, -3

A

Ficolines, opsoniseren en activeren via MBL de lectine route

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12
Q

CRP, SAP, PTX3

A

Pentraxines herkennen en activeren via C1q de complement cascade

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13
Q

Opsonine receptoren

A

Fc-receptor: detecteert constante domein Ig
Complement receptor

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14
Q

Microbe-ligand receptoren

A

Scavenger receptor: herstelt homeostase en fagocytose
C-type lectine: (in)activeren fagocytose en signalering

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15
Q

Supplementaire receptoren

A

TLR, RIG-1, NOD-like, DNA-sense

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16
Q

TLR effect

A

bindt adaptor eiwitten → activatie proteine kinases → activatie Tf

17
Q

TLR1

A

Gram negatieve bacterien

18
Q

TLR2

A

Gram positieve bacterien, schimmels, mycoplasma

19
Q

TLR3

A

RNA-virussen

20
Q

TLR4

A

Gram negatieve bacterien

21
Q

TLR5

A

Gram negatieve bacterien met flagellen

22
Q

TLR6

A

Gram positieve bacterien, mycoplasma

23
Q

TLR7

A

RNA-virussen

24
Q

TLR8

A

RNA-virussen

25
Q

TLR9

A

DNA-virussen, bacterien

'2B1 (4 decks)

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