Inhibitors of Protein Synthesis (abtcs)

Question 1

Name the drugs (9)

Answer 1

Aminoglycosides
Tetracylcines
Tigecycline
Chloramphenicol
Macroglides (erythomycin, azithromycin)
Clindamycin
Quinopristin/Dalfopristin
Linezolid
Muciprocin

Question 2

Which protein synthesis inhibs are good for G+ only?

Answer 2

macroglides
clindamycin
quinopristin/dalfopristin
linezolid
muciprocin

Question 3

Which protein synthesis inhibs are good for G- only, including pseudomonas?

Answer 3

aminoglycosides

Question 4

Which protein synthesis inhibs are cidal?

Answer 4

aminoglycosides
quinopristin/dalfopristin
muciprocin (at high dose)

Question 5

Which protein synthesis inhibs are static?

Answer 5

tetracyclines
tigecylines
chrloramphenicol
macroglides
clindamycin
linezoid
muciprocin (low dose)

Question 6

Which protein synthesis inhibs have serious side effects?

Answer 6

tetracycline: binds to teeth and bone, if you eat old drugs you get fanconi syndrome and your kidneys are fucked
chloramphenicol: aplastic anemia (80% fatal), gray baby syndrome
clindamycin: can cause c. diff infection that needs to be treated with other drugs

Question 7

Which protein synthesis inhibs are good VRSE/MRSA?

Answer 7

quinopristin/dalfopristin
linezoid
muciprocin

Question 8

Which protein synthesis inhibs are concentration dependent?

Answer 8

aminoglycosides