Inhibitors of Cell Wall Synthesis - (Other)

Question 0

Other cell wall inhibitors include?

Answer 0

1) Fosfomycin (oral) - excreted in breast milk + urine

(Broad spectrum [G+ve & -ve; synergistic w/ B-lactams, Aminoglycosides or quinolones; UTI in women & girls >5yrs, Prophylaxis + diagnosis for transurethral procedures in Men]; GIT problems + rashes; D/I = metoclopramide [dec. conc.]; C/I = renal failure, pregnancy & lactation)

Question 1

Glycopeptides include?

Answer 1

1) Vancomycin
2) Teicoplanin

(slow IV infusion because poorly absorbed orally and IM infusion is painful; life threatening conditions - restricted to Cloxacillin-resistant staphylococci & penicillin-resistant enterococci, prophylaxis for endocarditis in penicillin allergic individuals; rashes, red man syndrome; D/I = ototoxic & nephrotoxic drugs [aminoglycosides]; C/I = renal impairment, neonates, hearing abnormalities, pregnancy)