Inhibitors Flashcards
What is an inhibitor?
A substance that reduces the rate of an enzyme controlled reaction by affecting the enzyme molecule.
What are the 2 types of inhibitors?
Competitive
Non competitive
What are competitive inhibitors?
Molecules with a similar shape to the substrate. Fit into the active site of an enzyme so substarte can’t enter- reaction can’t happen
What are reversible inhibitors?
Inhibitors that occupy the active site of an enzyme temporarily. Substrate can enter after inhibitor leaves.
What are Non competitive inhibitors?
Inhibitors that don’t have a similar shape to substrate.
Where do non competitive inhibitors bind to enzymes?
Bind to the side of he enzyme away from the active site
What effect on an enzymes shape do non competitive inhibitirs have?
Inhibitor distorts tertiary structure.
Changes shape of active site so substarte can’t fit.
What is the name for the place where a non competitive inhibitor binds to an enzyme?
Allosteric site
What is another name for non competitive inhibitors?
Allosteric inhibitors
What effect does an increase it substrate concentration have with non competitive inhibitors?
No effect as active site not being fought over.
Are non competitive inhibitors reversible?
Reversible and non reversible
What is a use for end-product inhibition?
Negative feedback
What is reversible inhibition useful?
Important in controlling rate of metabolic pathways.
