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Farmaco > Inhibitori Parasimpatic > Flashcards

Inhibitori Parasimpatic Flashcards

1
Q

Antimuscarinice: alcaloizi naturali

A

-atropina
-scopolamina

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2
Q

Antimuscarinice: amine cuaternare in terapia GIT sau GUT

A

-butilscopolamina
-propantelina, metantelina
-metscopolamina
-clidinium
-isopropamida
-mepenzolqt
- glicopirolat
-oxifenonium
-tridihetetil
-trospium, emepronium

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3
Q

Antimuscarinice: amine tertiare in GUT si GIT

A

-pirenzepina, telenzepina
- diciclomin, oxifenciclimin
- oxibutinin, tolterodin, propiverin
- solifenacin, darifenacin

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4
Q

Antimuscarinice: amine cuaternare in AB:

A
  • ipratrooium, oxitropium (scurt)
  • tiotropium (lung)
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5
Q

Antimuscarinice: amine tertiare in Parkinson:

A
  • benztropina
  • trihexifenidil, orfenadina, biperiden, prociclidina, difenciclimin
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6
Q

Anticolinergice centrale ca miorelaxanre:

A
  • clorzoxazona, ciclobenzapina
  • carisoprodol, clorfenezina, metaxalone, metocarbamol, orfenadina
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7
Q

In oftalmologie:

A

Homatropina, Ciclopentolat, Tropicamida

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8
Q

Butilscopolamina:

A

Antagonist neselectiv pe RM:
- antispastic la GIT si GUT;
- premedicatie in anestezie;
- antiemeti ;

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9
Q

Pirenzepina, Telenzepina:

A

Antagonist selectiv pe RM1;
- inhiba s. gastrica si s. de pepsina;
- antispastic la GIT:
- pt pac. cu tahiaritmii asociate;

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10
Q

Propantelina:

A
  • antispastic la GIT
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11
Q

Trospium

A
  • tratament incont. urinara;
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12
Q

Diciclomin

A
  • actiune directa pe m. neteda;
  • pt IBS
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13
Q

Oxibutinin

A
  • contractia m. vezical, relaxarea m. detrusor, cresterea capacitatii v. urinare;
  • pt. Incint. urinara (din boli neurologice)
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14
Q

Darifenacin, Solifenacin:

A
  • antagonisti selectivi pe RM3 respectiv RM1,3;
  • pt incont. urinara, vezica neurologica
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15
Q

Ipratropium, Oxitropium, Tiotropium:

A
  • pt AB;
  • creste vascozitatea secretiei bronsice;
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16
Q

Toxina botulinica: efecte

A
  • inhiba elib Ach;
  • in spasm al m. globilor oculari, acalazia cardiei;
  • nevralgia de trigemen, lombalgii, dureri miofasciale;
  • reduce riduri;
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17
Q

Toxina botulinica: efecte adverse

A
  • disfagie;
  • uscaciunea gurii;
  • ptoza palpebrala;
  • r. imun. tip I;
  • atrofie musculara;
18
Q

Toxina botulinica: contraindicatii:

A
  • sarcina, alaptare;
  • miastenia gravis;
  • chimioterapie AB;
19
Q

Blocante ale RN: la nivelul ggl. vegetativi:

A
  • derivati amoniu cuaternar;
  • str. cu functii amidice secundare;
  • str. cu functii amidice tertiare;
  • derivati sulfonici;
20
Q

Blocante ale RN: la niv. ggl. vegetativi:
Camsilat de trimetafan: indicatii

A
  • crize acute de HTA;
  • in realizarea unei hipotensiuni controlate, pt a reduce hemoragia in chir. oftalmica si neurochir;
21
Q

Blocante ale RN: la niv. ggl. vegetativi:
Camsilat de trimetafan: efecte adverse:

A
  • simpatoplegie (hTA ortostatica marcata, disf. sexuala);
  • parasimpatoplegie ( constipatie, retentie urinara, precip. criza de glaucom, iscaciunea gurii);
  • uneori alergic (cont. histamina);
22
Q

Blocante ale RN: la niv. ggl. vegetativi:
Derivati de amoniu cuaternar:

A
  • hexametoniu;
  • tetraetilamoniu;
  • pentolinium;
  • decametoniu;
  • bromura de azamethoniu;
23
Q

Blocante ale RN: la niv. ggl. vegetativi:
Cu functii amidice secundare

A
  • mecamilamina
24
Q

Blocante ale RN: la niv. ggl. vegetativi:
Cu functii amidice tertiare:

A
  • pempidina
25
Q

Blocante ale RN: la niv. ggl. vegetativi:
Derivati sulfonici:

A
  • camsilat de trimetafan
26
Q

Blocante ale RN: la niv. JNM:

A
  • curatizante nedepolarizante (ordin I, pahicurare);
  • curatizante depolarizante (ordin II, leptocurare);
27
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Derivati isochinolinici:

A
  • D-tubocurarina;
  • atracurium;
  • cisatracurium;
  • doxacurium;
  • mivacurium;
  • metocurine;
28
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Derivati steroidieni:

A
  • pipercuronium;
  • pancuronium;
  • rocuronium;
  • vecuronium;
29
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
D-Tubocurarina:

A
  • nu relax bine glota;
  • elib histamina -> hTA si bronhoC;
  • hTA prin ef ganglioplegic si blocarea MSR;
  • scade coag sg;
  • nu are act. pe RM2 cardiaci;
30
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Atracurium:

A
  • metab tip Hofman (autometab la t corpului si pH fiziologic);
  • eliberare redusa de histamina;
31
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Cisatracurium si Doxacurium:

A
  • nu elib histamina;
  • nu are ef pe RNn,M2 cardiaci;
32
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Mivacurium

A
  • nu infl. RNn;
  • nu det. ef pe RM2 cardiaci;
  • elib redusa de histamina;
33
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:

Metocurine:

A
  • ef ganglioplegice reduse;
  • elib redusa de histamina;
  • nu infl RM2 cardiaci;
34
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Pancuronium:

A
  • blocheaza moderat RM2 cardiaci;
35
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Rocuronium:

A
  • blocare redusa a RM2 cardiaci;
36
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Derivatii steroidieni:

A

Nu det ef de tip ganglioplegic si nu elibereaza histamina

37
Q

Blocante ale RN: la niv. JNM:
Curatizante nedepolarizante:
Galamina:

A
  • antagonist alosteric pe RM2 cardiaci - tahic;
  • nu are ef ganglioplegic si nu elib histamina;
  • nu relax glota bine;
38
Q

Blocante ale RN: la niv. JNM:
Curatizante depolarizante:
Succinilcolina: efecte

A
  • relaxarea m striate;
  • hiperpotasemii;
39
Q

Blocante ale RN: la niv. JNM:
Curatizante depolarizante:
Succinilcolina: contraindicatii:

A
  • insuf renala;
  • arsuri;
  • paralizii/plegii musculare;
  • tublurari de ritm;
40
Q

Blocante ale RN: la niv. JNM:
Curatizante depolarizante:
Succinilcolina: avantaje

A
  • instalare si incetare rapida;
  • f buna relaxare a glotei;
41
Q

Blocante ale RN: la niv. JNM:
Curatizante depolarizante:
Succinilcolina: dezavantaje

A
  • lipsa antidot;
  • dureri musc la revenirea din curarizare;

Farmaco (2 decks)

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