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Inhibitori Parasimpatic Flashcards

1
Q

Antimuscarinice: alcaloizi naturali

A

-atropina
-scopolamina

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2
Q

Antimuscarinice: amine cuaternare in terapia GIT sau GUT

A

-butilscopolamina
-propantelina, metantelina
-metscopolamina
-clidinium
-isopropamida
-mepenzolqt
- glicopirolat
-oxifenonium
-tridihetetil
-trospium, emepronium

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3
Q

Antimuscarinice: amine tertiare in GUT si GIT

A

-pirenzepina, telenzepina
- diciclomin, oxifenciclimin
- oxibutinin, tolterodin, propiverin
- solifenacin, darifenacin

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4
Q

Antimuscarinice: amine cuaternare in AB:

A
  • ipratrooium, oxitropium (scurt)
  • tiotropium (lung)
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5
Q

Antimuscarinice: amine tertiare in Parkinson:

A
  • benztropina
  • trihexifenidil, orfenadina, biperiden, prociclidina, difenciclimin
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6
Q

Anticolinergice centrale ca miorelaxanre:

A
  • clorzoxazona, ciclobenzapina
  • carisoprodol, clorfenezina, metaxalone, metocarbamol, orfenadina
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7
Q

In oftalmologie:

A

Homatropina, Ciclopentolat, Tropicamida

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8
Q

Butilscopolamina:

A

Antagonist neselectiv pe RM:
- antispastic la GIT si GUT;
- premedicatie in anestezie;
- antiemeti ;

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9
Q

Pirenzepina, Telenzepina:

A

Antagonist selectiv pe RM1;
- inhiba s. gastrica si s. de pepsina;
- antispastic la GIT:
- pt pac. cu tahiaritmii asociate;

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10
Q

Propantelina:

A
  • antispastic la GIT
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11
Q

Trospium

A
  • tratament incont. urinara;
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12
Q

Diciclomin

A
  • actiune directa pe m. neteda;
  • pt IBS
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13
Q

Oxibutinin

A
  • contractia m. vezical, relaxarea m. detrusor, cresterea capacitatii v. urinare;
  • pt. Incint. urinara (din boli neurologice)
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14
Q

Darifenacin, Solifenacin:

A
  • antagonisti selectivi pe RM3 respectiv RM1,3;
  • pt incont. urinara, vezica neurologica
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15
Q

Ipratropium, Oxitropium, Tiotropium:

A
  • pt AB;
  • creste vascozitatea secretiei bronsice;
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16
Q

Toxina botulinica: efecte

A
  • inhiba elib Ach;
  • in spasm al m. globilor oculari, acalazia cardiei;
  • nevralgia de trigemen, lombalgii, dureri miofasciale;
  • reduce riduri;
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17
Q

Toxina botulinica: efecte adverse

A
  • disfagie;
  • uscaciunea gurii;
  • ptoza palpebrala;
  • r. imun. tip I;
  • atrofie musculara;
18
Q

Toxina botulinica: contraindicatii:

A
  • sarcina, alaptare;
  • miastenia gravis;
  • chimioterapie AB;
19
Q

Blocante ale RN: la nivelul ggl. vegetativi:

A
  • derivati amoniu cuaternar;
  • str. cu functii amidice secundare;
  • str. cu functii amidice tertiare;
  • derivati sulfonici;
20
Q

Blocante ale RN: la niv. ggl. vegetativi:
Camsilat de trimetafan: indicatii

A
  • crize acute de HTA;
  • in realizarea unei hipotensiuni controlate, pt a reduce hemoragia in chir. oftalmica si neurochir;
21
Q

Blocante ale RN: la niv. ggl. vegetativi:
Camsilat de trimetafan: efecte adverse:

A
  • simpatoplegie (hTA ortostatica marcata, disf. sexuala);
  • parasimpatoplegie ( constipatie, retentie urinara, precip. criza de glaucom, iscaciunea gurii);
  • uneori alergic (cont. histamina);
22
Q

Blocante ale RN: la niv. ggl. vegetativi:
Derivati de amoniu cuaternar:

A
  • hexametoniu;
  • tetraetilamoniu;
  • pentolinium;
  • decametoniu;
  • bromura de azamethoniu;
23
Q

Blocante ale RN: la niv. ggl. vegetativi:
Cu functii amidice secundare

A
  • mecamilamina
24
Q

Blocante ale RN: la niv. ggl. vegetativi:
Cu functii amidice tertiare:

25
Blocante ale RN: la niv. ggl. vegetativi: Derivati sulfonici:
- camsilat de trimetafan
26
Blocante ale RN: la niv. JNM:
- curatizante nedepolarizante (ordin I, pahicurare); - curatizante depolarizante (ordin II, leptocurare);
27
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Derivati isochinolinici:
- D-tubocurarina; - atracurium; - cisatracurium; - doxacurium; - mivacurium; - metocurine;
28
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Derivati steroidieni:
- pipercuronium; - pancuronium; - rocuronium; - vecuronium;
29
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: D-Tubocurarina:
- nu relax bine glota; - elib histamina -> hTA si bronhoC; - hTA prin ef ganglioplegic si blocarea MSR; - scade coag sg; - nu are act. pe RM2 cardiaci;
30
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Atracurium:
- metab tip Hofman (autometab la t corpului si pH fiziologic); - eliberare redusa de histamina;
31
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Cisatracurium si Doxacurium:
- nu elib histamina; - nu are ef pe RNn,M2 cardiaci;
32
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Mivacurium
- nu infl. RNn; - nu det. ef pe RM2 cardiaci; - elib redusa de histamina;
33
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Metocurine:
- ef ganglioplegice reduse; - elib redusa de histamina; - nu infl RM2 cardiaci;
34
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Pancuronium:
- blocheaza moderat RM2 cardiaci;
35
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Rocuronium:
- blocare redusa a RM2 cardiaci;
36
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Derivatii steroidieni:
Nu det ef de tip ganglioplegic si nu elibereaza histamina
37
Blocante ale RN: la niv. JNM: Curatizante nedepolarizante: Galamina:
- antagonist alosteric pe RM2 cardiaci - tahic; - nu are ef ganglioplegic si nu elib histamina; - nu relax glota bine;
38
Blocante ale RN: la niv. JNM: Curatizante depolarizante: Succinilcolina: efecte
- relaxarea m striate; - hiperpotasemii;
39
Blocante ale RN: la niv. JNM: Curatizante depolarizante: Succinilcolina: contraindicatii:
- insuf renala; - arsuri; - paralizii/plegii musculare; - tublurari de ritm;
40
Blocante ale RN: la niv. JNM: Curatizante depolarizante: Succinilcolina: avantaje
- instalare si incetare rapida; - f buna relaxare a glotei;
41
Blocante ale RN: la niv. JNM: Curatizante depolarizante: Succinilcolina: dezavantaje
- lipsa antidot; - dureri musc la revenirea din curarizare;

Farmaco (2 decks)

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